一例罕见的VII因子缺乏症患者的双瓣膜手术。

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Perfusion-Uk Pub Date : 2024-11-01 Epub Date: 2023-10-31 DOI:10.1177/02676591231211502
Friederike I Schoettler, Ali Fatehi Hassanabad, Michael H Chiu, Andre Ferland, Corey Adams
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引用次数: 0

摘要

对出血患者进行心脏手术带来了重大挑战,因为这些患者因过度出血而出现并发症的风险增加。尽管其罕见,但因子VII(FVII)缺乏症患者可能需要进行侵入性手术,如心脏手术。然而,我们缺乏关于其术前、围术期和术后管理的指导方针。由于FVII缺乏是罕见的,它似乎不太可能设计和学习大型临床研究。相反,我们需要将临床决策建立在单一报告病例和登记数据的基础上。在此,我们介绍了一例罕见的FVII缺乏症患者接受双瓣膜手术。术前,给予活化的重组FVII(rFVIIa)以降低出血风险。尽管如此,患者还是出现了大出血。该病例强调了FVII缺乏在接受心脏手术的患者中的重要性,并强调了为这些患者充分和适当输血的重要性。
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The rare case of double valve surgery in a patient with factor VII deficiency.

Performing cardiac surgery on patients with bleeding diatheses poses significant challenges since these patients are at an increased risk for complications secondary to excessive bleeding. Despite its rarity, patients with factor VII (FVII) deficiency may require invasive procedures such as cardiac surgery. However, we lack guidelines on their pre-, peri-, and post-operative management. As FVII deficiency is rare, it seems unlikely to design and learn from large clinical studies. Instead, we need to base our clinical decision-making on single reported cases and registry data. Herein, we present the rare case of a patient with FVII deficiency who underwent double valve surgery. Pre-operatively, activated recombinant FVII (rFVIIa) was administered to reduce the risk of bleeding. Nevertheless, the patient experienced major bleeding. This case highlights the significance of FVII deficiency in patients undergoing cardiac surgery and emphasizes the importance of adequate and appropriate transfusion of blood products for these patients.

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来源期刊
Perfusion-Uk
Perfusion-Uk 医学-外周血管病
CiteScore
3.00
自引率
8.30%
发文量
203
审稿时长
6-12 weeks
期刊介绍: Perfusion is an ISI-ranked, peer-reviewed scholarly journal, which provides current information on all aspects of perfusion, oxygenation and biocompatibility and their use in modern cardiac surgery. The journal is at the forefront of international research and development and presents an appropriately multidisciplinary approach to perfusion science.
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