猕猴外侧前额叶皮层丘脑连接的梯度。

IF 2.6 3区 医学 Q2 BEHAVIORAL SCIENCES Frontiers in Integrative Neuroscience Pub Date : 2023-10-16 eCollection Date: 2023-01-01 DOI:10.3389/fnint.2023.1239426
Elena Borra, Marianna Rizzo, Giuseppe Luppino
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引用次数: 0

摘要

在灵长类动物的大脑中,外侧前额叶皮层(LPF)是一个巨大的异质区域,主要参与行为的认知控制,由几个连接和功能不同的区域组成。对猕猴的研究提供了证据,证明了位于不同背中央水平的建筑区域之间的皮层连接的独特模式,以及三个主要建筑LPF区域(46d、46v和12r)顶叶和额叶连接的喙顶梯度。在本研究中,基于在不同背中央和头枕皮质水平进行的示踪剂注射,我们检查了丘脑对LPF的投影,以检查丘脑LPF投影的地形图中反映了皮质连接的细粒度连接梯度的程度。结果显示,到目前为止,丘脑输入LPF的主要来源是背内侧核(MD)上的头端到尾端LPF区的映射,其中投射到更多尾部LPF扇区的MD区位于比投射到中间LPF扇区更多的头端。此外,突出到罗斯托LPF区的MD区在罗斯托方向上往往更为广泛。一个头外侧MD扇区似乎是涉及动眼器额叶结构域的尾侧前额叶区域的常见投射源,在很大程度上是腹侧LPF的尾侧和腹侧MD扇区,在大部分背侧LPF中是中侧和背侧MD扇区。LPF区域的额外拓扑组织投射源于枕内侧核,而来自前内侧核的投射选择性地靶向LPF的更多头侧部分。因此,目前的数据表明,MD-LPF投影的拓扑结构不遵循简单的拓扑规则,而是主要根据函数标准进行组织。
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Gradients of thalamic connectivity in the macaque lateral prefrontal cortex.

In the primate brain, the lateral prefrontal cortex (LPF) is a large, heterogeneous region critically involved in the cognitive control of behavior, consisting of several connectionally and functionally distinct areas. Studies in macaques provided evidence for distinctive patterns of cortical connectivity between architectonic areas located at different dorsoventral levels and for rostrocaudal gradients of parietal and frontal connections in the three main architectonic LPF areas: 46d, 46v, and 12r. In the present study, based on tracer injections placed at different dorsoventral and rostrocaudal cortical levels, we have examined the thalamic projections to the LPF to examine to what extent fine-grained connectional gradients of cortical connectivity are reflected in the topography of thalamo-LPF projections. The results showed mapping onto the nucleus medialis dorsalis (MD), by far the major source of thalamic input to the LPF, of rostral-to-caudal LPF zones, in which MD zones projecting to more caudal LPF sectors are located more rostral than those projecting to intermediate LPF sectors. Furthermore, the MD zones projecting to the rostral LPF sectors tended to be much more extensive in the rostrocaudal direction. One rostrolateral MD sector appeared to be a common source of projections to caudal prefrontal areas involved in the oculomotor frontal domain, a more caudal and ventral MD sector to a large extent of the ventral LPF, and middle and dorsal MD sectors to most of the dorsal LPF. Additional topographically organized projections to LPF areas originated from the nucleus pulvinaris medialis and projections from the nucleus anterior medialis selectively targeted more rostral sectors of LPF. Thus, the present data suggest that the topography of the MD-LPF projections does not adhere to simple topological rules, but is mainly organized according to functional criteria.

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来源期刊
Frontiers in Integrative Neuroscience
Frontiers in Integrative Neuroscience Neuroscience-Cellular and Molecular Neuroscience
CiteScore
4.60
自引率
2.90%
发文量
148
审稿时长
14 weeks
期刊介绍: Frontiers in Integrative Neuroscience publishes rigorously peer-reviewed research that synthesizes multiple facets of brain structure and function, to better understand how multiple diverse functions are integrated to produce complex behaviors. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Our goal is to publish research related to furthering the understanding of the integrative mechanisms underlying brain functioning across one or more interacting levels of neural organization. In most real life experiences, sensory inputs from several modalities converge and interact in a manner that influences perception and actions generating purposeful and social behaviors. The journal is therefore focused on the primary questions of how multiple sensory, cognitive and emotional processes merge to produce coordinated complex behavior. It is questions such as this that cannot be answered at a single level – an ion channel, a neuron or a synapse – that we wish to focus on. In Frontiers in Integrative Neuroscience we welcome in vitro or in vivo investigations across the molecular, cellular, and systems and behavioral level. Research in any species and at any stage of development and aging that are focused at understanding integration mechanisms underlying emergent properties of the brain and behavior are welcome.
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