Von Willebrand因子原肽作为系统性硬化症（硬皮病）疾病活动的标志物。

Arthritis research Pub Date : 2001-01-01 Epub Date: 2001-02-19 DOI:10.1186/ar295

A Scheja, A Akesson, P Geborek, M Wildt, C B Wollheim, F A Wollheim, U M Vischer

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引用次数: 53

摘要

在连续44例系统性硬化症（SSc）患者中，血管性血友病因子（vWf）的血浆浓度高于vWf前肽的血浆浓度，但前肽在患者亚组中的变异性较小。在早期肺部受累的患者中观察到较高的前肽值。与vWf相比，前肽与活性的生化标记物的相关性也很明显。我们的结果表明，尽管与vWf相比，前肽的循环半衰期更短，血浆浓度更低，但它在评估SSc的疾病活性方面更有用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma).

In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

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Arthritis research

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