Quezia Damaris Jones Severino Vasconcelos, Marisa Jadna Silva Frederico, Renata de Sousa Alves, Tereza de Jesus Pinheiro Gomes Bandeira, Maria Elisabete Amaral de Moraes, Gislei Frota Aragão
{"title":"补充乳清蛋白对具有丙戊酸诱导的自闭症症状的Wistar大鼠肠道微生物群的影响。","authors":"Quezia Damaris Jones Severino Vasconcelos, Marisa Jadna Silva Frederico, Renata de Sousa Alves, Tereza de Jesus Pinheiro Gomes Bandeira, Maria Elisabete Amaral de Moraes, Gislei Frota Aragão","doi":"10.2217/fmb-2023-0051","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> To evaluate the effects of whey protein (WP) supplementation (1.24 mg/g, 24 days) in rats with autism spectrum disorder (ASD) induced by valproic acid (400 mg/kg, single dose). <b>Materials & methods:</b> Wistar rats (14 days old) were divided into four groups: control, ASD, ASD plus WP and WP. <b>Results:</b> WP increased bacterial diversity and the number of colonies. Bacteria from the Firmicutes phylum were predominantly found in the supplemented groups (p < 0.05). WP also improved the animals' memory in the Y-maze test and decreased the time that male animals spent in the 'solitary chamber' (p < 0.05). <b>Conclusion:</b> WP supplementation positively influenced gut microbiota, along with memory.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"213-226"},"PeriodicalIF":2.5000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of whey protein supplementation on gut microbiota of Wistar rats with valproic acid-induced autism symptoms.\",\"authors\":\"Quezia Damaris Jones Severino Vasconcelos, Marisa Jadna Silva Frederico, Renata de Sousa Alves, Tereza de Jesus Pinheiro Gomes Bandeira, Maria Elisabete Amaral de Moraes, Gislei Frota Aragão\",\"doi\":\"10.2217/fmb-2023-0051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> To evaluate the effects of whey protein (WP) supplementation (1.24 mg/g, 24 days) in rats with autism spectrum disorder (ASD) induced by valproic acid (400 mg/kg, single dose). <b>Materials & methods:</b> Wistar rats (14 days old) were divided into four groups: control, ASD, ASD plus WP and WP. <b>Results:</b> WP increased bacterial diversity and the number of colonies. Bacteria from the Firmicutes phylum were predominantly found in the supplemented groups (p < 0.05). WP also improved the animals' memory in the Y-maze test and decreased the time that male animals spent in the 'solitary chamber' (p < 0.05). <b>Conclusion:</b> WP supplementation positively influenced gut microbiota, along with memory.</p>\",\"PeriodicalId\":12773,\"journal\":{\"name\":\"Future microbiology\",\"volume\":\" \",\"pages\":\"213-226\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.2217/fmb-2023-0051\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/11/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.2217/fmb-2023-0051","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/7 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Effects of whey protein supplementation on gut microbiota of Wistar rats with valproic acid-induced autism symptoms.
Aim: To evaluate the effects of whey protein (WP) supplementation (1.24 mg/g, 24 days) in rats with autism spectrum disorder (ASD) induced by valproic acid (400 mg/kg, single dose). Materials & methods: Wistar rats (14 days old) were divided into four groups: control, ASD, ASD plus WP and WP. Results: WP increased bacterial diversity and the number of colonies. Bacteria from the Firmicutes phylum were predominantly found in the supplemented groups (p < 0.05). WP also improved the animals' memory in the Y-maze test and decreased the time that male animals spent in the 'solitary chamber' (p < 0.05). Conclusion: WP supplementation positively influenced gut microbiota, along with memory.
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Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
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