水貂极高密度α2脂蛋白等位决定因子Lpm7和Lpm8的分子分布

O.K. Baranov, V.I. Yermolaev
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引用次数: 6

摘要

琼脂凝胶双扩散实验表明,水貂的高密度脂蛋白Lpm7和Lpm8位于不同的分子上。具有Lpm7和Lpm8的分子没有其他已知的Lpm同种决定簇。这些结果扩展了我们早期对脂蛋白分子上Lpm1、Lpm2、Lpm3、Lpm4和Lpm5分布的观察。结果表明,水貂血清中的Lpm脂蛋白由几种类型的分子表示。在其物种特异性抗原特性上相同,并且每个都具有独特的同种决定簇。Lpm7和Lpm8在分子中的分布模式支持了单基因遗传的同种异体群由紧密连接的结构基因控制的说法。
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Molecular distribution of allotypic determinants Lpm7 and Lpm8 of mink very high density α2-lipoprotein

Agar gel double-diffusion experiments demonstrated that the allodeterminants Lpm7 and Lpm8, very high density lipoproteins of mink, reside on different molecules. Molecules possessing Lpm7 and Lpm8 have no other known Lpm-allodeterminants. These results extend our earlier observations on the distribution of Lpm1, Lpm2, Lpm3, Lpm4 and Lpm5 on lipoprotein molecules. It is concluded that Lpm-lipoproteins from mink sera are represented by molecules of several types. identical in their species-specific antigenic properties and each having a unique allodeterminant. The distribution patterns of Lpm7 and Lpm8 among molecules support the suggestion that monogenically inherited allogroups are controlled by closely-linked structural genes.

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