一种能够从DNA混合物中进行法医遗传谱系调查的方法

IF 0.5 Q4 GENETICS & HEREDITY Forensic Science International: Genetics Supplement Series Pub Date : 2022-12-01 DOI:10.1016/j.fsigss.2022.10.020

Rebecca Mitchell, Sana Enke, Kim Eskey, Tracy Ferguson, Rebecca Just

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引用次数: 3

摘要

证据样本中存在一个以上的DNA贡献者，可能会阻止使用法医遗传谱系学来开发调查线索的尝试。为了解决这个问题，我们开发了一个工作流程，将SNP混合物反褶积为适合与系谱数据库匹配的单一源剖面。使用该方法，使用商业SNP分型试剂盒测定的两个贡献者DNA混合物可以产生主要和次要贡献者的信息匹配结果。

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A method to enable forensic genetic genealogy investigations from DNA mixtures

The presence of more than one DNA contributor in an evidentiary sample may preclude attempts to use forensic genetic genealogy to develop an investigative lead. To address this issue, we developed a workflow for deconvolution of SNP mixtures into single source profiles that are suitable for matching against a genealogical database. Using the method, two-contributor DNA mixtures assayed using a commercial SNP typing kit can produce informative match results for both major and minor contributors.

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来源期刊

Forensic Science International: Genetics Supplement Series Medicine-Pathology and Forensic Medicine

CiteScore

0.40

自引率

0.00%

发文量

122

审稿时长

25 days

期刊介绍： The Journal of Forensic Science International Genetics Supplement Series is the perfect publication vehicle for the proceedings of a scientific symposium, commissioned thematic issues, or for disseminating a selection of invited articles. The Forensic Science International Genetics Supplement Series is part of a duo of publications on forensic genetics, published by Elsevier on behalf of the International Society for Forensic Genetics.