单细胞工厂中单萜吲哚生物碱的生物生产

Engineering Microbiology Pub Date : 2022-12-01 DOI:10.1016/j.engmic.2022.100050

Jianping Huang , Shengxiong Huang

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引用次数: 3

摘要

长春花碱和长春花碱是抗癌药物长春花碱工业生产的直接前体，它们的从头生物合成已在酵母细胞工厂中实现。到目前为止，这是从植物成功转移到微生物的最长的天然产物生物合成途径，表明通过合成基因组工程在酵母中生产3000多种其他单萜吲哚生物碱的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bioproduction of monoterpene indole alkaloids in a single cell factory

The de novo biosynthesis of vindoline and catharanthine, the direct precursors used for industrial production of the anti-cancer drug vinblastine, has been achieved in the yeast cell factory. To date, this is the longest natural product biosynthesis pathway that has been successfully transferred from plants to microorganisms, indicating the possibility of producing more than 3,000 other monoterpene indole alkaloids in yeast by synthetic genome engineering.

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来源期刊

Engineering Microbiology

CiteScore

3.90

自引率

0.00%

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