苏法替尼联合卡雷珠单抗作为一种有价值的小细胞肺癌癌症晚期患者的第三线抢救疗法:病例报告和文献综述。

IF 1.8 4区 医学 Q3 ONCOLOGY Anti-Cancer Drugs Pub Date : 2024-03-01 Epub Date: 2023-11-21 DOI:10.1097/CAD.0000000000001552
Chi Pan, Tao Yu, Li Han, Daxuan Hao, Ming Yang, Lin Li, Laili Chu, Qingtao Ni
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引用次数: 0

摘要

癌症是最常见、发病率最高的恶性肿瘤之一。基因突变在小细胞肺癌(SCLC)中很少见,因此靶向治疗只是三线建议。苏法替尼(Sulanda)是一种口服血管免疫激酶抑制剂,用于治疗实体瘤。我们报告了一例小细胞肺癌,用苏法替尼联合卡雷珠单抗治疗,在我们科室取得了良好的治疗效果。患者经历了超过18个月的无进展生存期和超过28个月的总生存期。这表明苏鲁法替尼联合卡雷珠单抗是SCLC患者的有效三线治疗方法。然而,所有SCLC患者对苏鲁法替尼治疗的有效率仍然未知,需要在大量人群中确定。
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Surufatinib combined camrelizumab as a valuable third-line rescue therapy for a patient with extensive-stage for small-cell lung cancer: a case report and literature review.

Lung cancer is one of the most common malignant tumors with the highest incidence. Gene mutations are rare in small-cell lung carcinoma (SCLC), resulting in targeted therapy being only a third-line recommendation. Surufatinib (Sulanda) is an oral angio-immune kinase inhibitor used to treat solid tumors. We report a case of SCLC treated with surufatinib combined with camrelizumab, with good therapeutic results in our department. The patient experienced over 18 months of progression-free survival and over 28 months of overall survival. This suggests that surufatinib combined with camrelizumab is an effective third-line treatment for SCLC patients. However, the response rate to surufatinib treatment in all patients with SCLC remains unknown and needs to be determined in a large population.

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来源期刊
Anti-Cancer Drugs
Anti-Cancer Drugs 医学-药学
CiteScore
3.80
自引率
0.00%
发文量
244
审稿时长
3 months
期刊介绍: Anti-Cancer Drugs reports both clinical and experimental results related to anti-cancer drugs, and welcomes contributions on anti-cancer drug design, drug delivery, pharmacology, hormonal and biological modalities and chemotherapy evaluation. An internationally refereed journal devoted to the fast publication of innovative investigations on therapeutic agents against cancer, Anti-Cancer Drugs aims to stimulate and report research on both toxic and non-toxic anti-cancer agents. Consequently, the scope on the journal will cover both conventional cytotoxic chemotherapy and hormonal or biological response modalities such as interleukins and immunotherapy. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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