{"title":"Gm系统的遗传学及其在免疫反应和疾病中的作用","authors":"JANARDAN P. PANDEY, H. HUGH FUDENBERG","doi":"10.1016/S0260-4639(22)00204-3","DOIUrl":null,"url":null,"abstract":"<div><p>Recent methods for detecting and quantifying immunoglobulin allotypes are discussed. Application of recombinant DNA technology to the study of immunoglobulin genes and its advantages and disadvantages, compared with the widely-used serological allotyping methods, are presented. Limitations of current disease association studies are mentioned. Anticipated advances in this area, together with the potential basic and clinical significance of findings from such investigations, are discussed.</p></div>","PeriodicalId":100282,"journal":{"name":"Clinics in Immunology and Allergy","volume":"4 3","pages":"Pages 641-645"},"PeriodicalIF":0.0000,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Perspectives on the Genetics of the Gm System and its Role in Immune Response and Diseases\",\"authors\":\"JANARDAN P. PANDEY, H. HUGH FUDENBERG\",\"doi\":\"10.1016/S0260-4639(22)00204-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Recent methods for detecting and quantifying immunoglobulin allotypes are discussed. Application of recombinant DNA technology to the study of immunoglobulin genes and its advantages and disadvantages, compared with the widely-used serological allotyping methods, are presented. Limitations of current disease association studies are mentioned. Anticipated advances in this area, together with the potential basic and clinical significance of findings from such investigations, are discussed.</p></div>\",\"PeriodicalId\":100282,\"journal\":{\"name\":\"Clinics in Immunology and Allergy\",\"volume\":\"4 3\",\"pages\":\"Pages 641-645\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinics in Immunology and Allergy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0260463922002043\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinics in Immunology and Allergy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0260463922002043","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Perspectives on the Genetics of the Gm System and its Role in Immune Response and Diseases
Recent methods for detecting and quantifying immunoglobulin allotypes are discussed. Application of recombinant DNA technology to the study of immunoglobulin genes and its advantages and disadvantages, compared with the widely-used serological allotyping methods, are presented. Limitations of current disease association studies are mentioned. Anticipated advances in this area, together with the potential basic and clinical significance of findings from such investigations, are discussed.
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