The Gabapentoids Conundrum: “Mind the Gabs”

Concerns about two Gabapentoids namely Gabapentin and Pregabalin have been raised for years. Both were introduced as anti-epileptic agents before finding a myriad of indications, not without controversy. Experts are divided about their safety; one camp defends their use the other flagging incidents of diversion, reports of abuse cases of overdosing and even mortality. This article presents alarming Middle Eastern example of a wave of Gabapentoids abuse, mostly Pregabalin, among patients seeking treatment at the National Rehabilitation Center, Abu Dhabiand UAE. It also provides an overview of indications, side effects, evidence for and against abuse and misuse potential, laboratory tests, all within the context of a substance use disorder rehabilitation service.