65岁以上慢性心力衰竭患者的老年特征:EUCALYPTUS研究数据

M. Fedin, N. Vorobyeva, A. Izyumov, K. Eruslanova, Y. Kotovskaya, O. Tkacheva
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The frequency of CHF in all subjects was 57,8 %, including 44,2 % in persons aged 65–74 years, 60,2 % in 75–84 years, 72,6 % in ≥ 85 years (p for a trend < 0,001). In patients with CHF, the frequency of 13 out of 15 GS was higher (except for orthostatic hypotension and malnutrition). One-way regression analysis showed that the presence of CHF is associated with an increase in the chances of having these GS by 1,3–1,9 times. Multivariate regression analysis adjusted for age and sex found that age was independently associated with the presence of CHF (odds ratio (OR) 1,06 for every 1 year; 95 % confidence interval (CI) 1,05–1,07; p < 0,001), basic dependence in everyday life (OR 1,22; 95 % CI 1,04–1,42; p = 0,015), probable depression (OR 1,35; 95 % CI 1,16–1,56; p < 0,001), fecal incontinence (OR 1,80; 95 % CI 1,21–2,69; p = 0,004) and chronic pain syndrome (OR 1,97; 95 % CI 1,58–2,45; p < 0,001).Conclusions. 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In persons aged ≥ 65 years, to estimate the prevalence of chronic heart failure (CHF), assess geriatric status and analyze associations of CHF with geriatric syndromes (GS).Design and methods. The study included 4308 people (30 % men) aged 65 to 107 years (mean age 78 ± 8 years) living in 11 regions of the Russian Federation, who were divided into 3 age subgroups (65–74 years, 75–84 years and ≥ 85 years). All participants underwent a comprehensive geriatric assessment, which consisted of two stages: 1) questioning according to a specially designed questionnaire; 2) objective examination. The presence of 15 GS was assessed. The presence of CHF was judged on the basis of the submitted medical documentation.Results. The frequency of CHF in all subjects was 57,8 %, including 44,2 % in persons aged 65–74 years, 60,2 % in 75–84 years, 72,6 % in ≥ 85 years (p for a trend < 0,001). 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引用次数: 0

摘要

目标。在年龄≥65岁的人群中,估计慢性心力衰竭(CHF)的患病率,评估老年状态并分析CHF与老年综合征(GS)的相关性。设计和方法。该研究纳入4308人(30%为男性),年龄65 ~ 107岁(平均年龄78±8岁),生活在俄罗斯联邦的11个地区,他们被分为3个年龄亚组(65 ~ 74岁,75 ~ 84岁和≥85岁)。所有参与者都接受了全面的老年评估,该评估包括两个阶段:1)根据专门设计的问卷进行提问;2)客观检查。评估了15例GS的存在。根据提交的医学文献判断是否存在CHF。CHF在所有受试者中的发生率为57.8%,其中65-74岁者为44.2%,75-84岁者为602%,≥85岁者为72.6% (p < 0.001)。在CHF患者中,15例GS中有13例的频率更高(除了直立性低血压和营养不良)。单因素回归分析显示,CHF的存在与发生这些GS的几率增加1,3 - 1,9倍相关。经年龄和性别校正的多因素回归分析发现,年龄与CHF存在独立相关(比值比(OR) 1.06 / 1年;95%置信区间(CI) 1,05 - 1,07;p < 0.001),日常生活中的基本依赖(OR 1,22;95% ci 1,04 - 1,42;p = 0.015),可能是抑郁症(OR 1,35;95% ci 1,16 - 1,56;p < 0.001),大便失禁(OR 1,80;95% ci 1,21 - 2,69;p = 0.004)和慢性疼痛综合征(OR 1,97;95% ci 1,58 - 2,45;p < 0.001)。在EUCALYPTUS研究中,首次获得了≥65岁人群中CHF患病率的国家数据,并研究了CHF与15gs之间的关系。
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Peculiarities of geriatric status in patients with chronic heart failure over the age of 65: data from the EUCALYPTUS study
Objective. In persons aged ≥ 65 years, to estimate the prevalence of chronic heart failure (CHF), assess geriatric status and analyze associations of CHF with geriatric syndromes (GS).Design and methods. The study included 4308 people (30 % men) aged 65 to 107 years (mean age 78 ± 8 years) living in 11 regions of the Russian Federation, who were divided into 3 age subgroups (65–74 years, 75–84 years and ≥ 85 years). All participants underwent a comprehensive geriatric assessment, which consisted of two stages: 1) questioning according to a specially designed questionnaire; 2) objective examination. The presence of 15 GS was assessed. The presence of CHF was judged on the basis of the submitted medical documentation.Results. The frequency of CHF in all subjects was 57,8 %, including 44,2 % in persons aged 65–74 years, 60,2 % in 75–84 years, 72,6 % in ≥ 85 years (p for a trend < 0,001). In patients with CHF, the frequency of 13 out of 15 GS was higher (except for orthostatic hypotension and malnutrition). One-way regression analysis showed that the presence of CHF is associated with an increase in the chances of having these GS by 1,3–1,9 times. Multivariate regression analysis adjusted for age and sex found that age was independently associated with the presence of CHF (odds ratio (OR) 1,06 for every 1 year; 95 % confidence interval (CI) 1,05–1,07; p < 0,001), basic dependence in everyday life (OR 1,22; 95 % CI 1,04–1,42; p = 0,015), probable depression (OR 1,35; 95 % CI 1,16–1,56; p < 0,001), fecal incontinence (OR 1,80; 95 % CI 1,21–2,69; p = 0,004) and chronic pain syndrome (OR 1,97; 95 % CI 1,58–2,45; p < 0,001).Conclusions. In the EUCALYPTUS study, for the first time, national data on the prevalence of CHF in people aged ≥ 65 years were obtained and associations between CHF and 15 GS were studied.
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来源期刊
Arterial Hypertension (Russian Federation)
Arterial Hypertension (Russian Federation) Medicine-Cardiology and Cardiovascular Medicine
CiteScore
0.90
自引率
0.00%
发文量
38
期刊介绍: The main aims of the Journal include collecting and generalizing the knowledge in hypertensiology; education and professional development of cardiologists and medical doctors of other specialties, who deal with different issues regarding diagnostics, management and prevention of hypertension in both clinical practice and research. The Journal also calls attention to the most urgent and up-to-date questions in hypertensiology, cardiology and related sciences. There are additional objectives, such as increasing the availability, accessibility and recognition of Russian medical scientific achievements at the international level by improving the quality of the publication and the way they are presented; enabling the exchange of opinions and information between scientists and their wider communication. The main criteria for publication selection fit with the mentioned objectives and include currency, singularity, scientific and practical novelty, applied relevance etc.
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