Y. Ozeki, T. Mizuguchi, N. Hirabayashi, M. Ogawa, N. Ohmura, Miyuki Moriuchi, N. Harada, N. Matsumoto, H. Kunugi
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A Case of Schizophrenia with Chromosomal Microdeletion of 17p11.2 Containing a Myelin-Related Gene PMP22
We report a patient with schizophrenia who had a chromosomal deletion of 17p11.2 containing a myelin- related gene PMP22 by using comparative genomic hybridization (CGH) array and quantitative PCR. Since genetic link- age to 17p11, reduced expression of PMP22, and alterations in myelination have previously been reported, this report fur- ther suggests an etiological role of PMP22 in schizophrenia.
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