{"title":"白蛋白微球用于吡罗昔康眼部给药","authors":"P. Giunchedi, P. Chetoni, U. Conte, M. Saettone","doi":"10.1211/146080800128735809","DOIUrl":null,"url":null,"abstract":"This investigation deals with the preparation, in-vitro characterization and preliminary in-vivo evaluation of albumin microspheres containing piroxicam. The albumin-piroxicam microspheres, designed for ocular administration, were prepared by a spray-drying technique. The morphological and dimensional characteristics of the particles were studied by scanning-electron microscopy and particle-size analysis. Their in-vitro release behaviour was investigated in pH 7-0 USP23 buffer by use of a flow-through apparatus. \n \n \n \nPiroxicam in the albumin microspheres dissolved more quickly in-vitro than did piroxicam powder. The pharmacokinetic profile of piroxicam in aqueous humour was investigated in albino rabbits. The albumin-piroxicam microspheres resulted in greater bioavailability of piroxicam than commercial piroxicam eyedrops.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"38 1","pages":"149-153"},"PeriodicalIF":0.0000,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"17","resultStr":"{\"title\":\"Albumin Microspheres for Ocular Delivery of Piroxicam\",\"authors\":\"P. Giunchedi, P. Chetoni, U. Conte, M. Saettone\",\"doi\":\"10.1211/146080800128735809\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This investigation deals with the preparation, in-vitro characterization and preliminary in-vivo evaluation of albumin microspheres containing piroxicam. The albumin-piroxicam microspheres, designed for ocular administration, were prepared by a spray-drying technique. The morphological and dimensional characteristics of the particles were studied by scanning-electron microscopy and particle-size analysis. Their in-vitro release behaviour was investigated in pH 7-0 USP23 buffer by use of a flow-through apparatus. \\n \\n \\n \\nPiroxicam in the albumin microspheres dissolved more quickly in-vitro than did piroxicam powder. The pharmacokinetic profile of piroxicam in aqueous humour was investigated in albino rabbits. The albumin-piroxicam microspheres resulted in greater bioavailability of piroxicam than commercial piroxicam eyedrops.\",\"PeriodicalId\":19946,\"journal\":{\"name\":\"Pharmacy and Pharmacology Communications\",\"volume\":\"38 1\",\"pages\":\"149-153\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacy and Pharmacology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1211/146080800128735809\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1211/146080800128735809","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Albumin Microspheres for Ocular Delivery of Piroxicam
This investigation deals with the preparation, in-vitro characterization and preliminary in-vivo evaluation of albumin microspheres containing piroxicam. The albumin-piroxicam microspheres, designed for ocular administration, were prepared by a spray-drying technique. The morphological and dimensional characteristics of the particles were studied by scanning-electron microscopy and particle-size analysis. Their in-vitro release behaviour was investigated in pH 7-0 USP23 buffer by use of a flow-through apparatus.
Piroxicam in the albumin microspheres dissolved more quickly in-vitro than did piroxicam powder. The pharmacokinetic profile of piroxicam in aqueous humour was investigated in albino rabbits. The albumin-piroxicam microspheres resulted in greater bioavailability of piroxicam than commercial piroxicam eyedrops.
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