Research progress on influencing factors of antiretroviral therapy withdrawal in HIV/AIDS patients

AIDS is a highly harmful infectious disease caused by human immunodeficiency virus (HIV), which requires HIV/AIDS patients to take medication on time and at the appropriate amount every day to effectively inhibit HIV replication in vivo. China has implemented antiretroviral therapy (ART) and expanded treatment strategy, including all eligible HIV-infected people into the treatment scope of treatment. More and more HIV-infected patients receive ART. At the same time, the number of HIV/AIDS patients who withdraw from ART (drug withdrawal and loss of follow-up) is also increasing year by year. In the long-term medication process of HIV/AIDS patients, various reasons such as adverse drug reactions, busy work, CD4, low selfmanagement ability of patients, economic conditions and other reasons lead to poor compliance of patients and high incidence of withdrawal. In China, ART treatment coverage of HIV/AIDS patients is required to be over 90%, and withdrawal has become the biggest threat to the coverage of ART treatment. In this paper, the influencing factors related to ART withdrawal of HIV/ AIDS patients were summarized to comprehensively understand the reasons for the possible withdrawal of ART therapy for HIV/ AIDS patients, and to provide measures to reduce the withdrawal and loss of follow-up of ART therapy for HIV/AIDS patients. 摘要 : 艾滋病是由人类免疫缺陷病毒(HIV)引起的一种危害性极大的传染病, 需要 HIV/AIDS 患者每日按时按量服 药才能有效抑制体内 HIV 复制。中国实施抗逆转录病毒疗法(ART)和扩大治疗策略将所有符合条件的 HIV 感染者纳人 治疗范围, 越来越多的 HIV 感染者接受ART,同时退出 (停药和失访)ART的 HIV/AIDS 患者人数也在逐年累加。在 HIV/AIDS 患者长期的服药过程中, 药物不良反应、工作繁忙、CD4、患者自我管理能力低、经济条件等各种原因, 导致患 者出现依从性不良 , 患者退出的发生率髙。中国遏制与防治艾滋病要求 HIV/AIDS 患者 ART 治疗覆盖率是90%以上, 退出已经成为影响ART治疗覆盖率的最大威胁。本文就 HIV/AIDS 患者 ART 退出相关影响因素进行综述, 全面了解 HIV/AIDS 患者ART治疗可能退出的原因以及提供减少 HIV/AIDS 患者ART治疗停药和失访相关措施。