{"title":"对手性、主链修饰肽核酸的见解:性质和生物活性。","authors":"Maria Moccia, Mauro F A Adamo, Michele Saviano","doi":"10.1080/1949095X.2015.1107176","DOIUrl":null,"url":null,"abstract":"<p><p>PNAs are emerging as useful synthetic devices targeting natural miRNAs. In particular 3 classes of structurally modified PNAs analogs are herein described, namely α, β and γ, which differ by their backbone modification. Their mode and binding affinity for natural nucleic acids and their use in medicinal chemistry as potential miRNA binders is discussed. </p>","PeriodicalId":50838,"journal":{"name":"Agricultural History","volume":"1 1","pages":"e1107176"},"PeriodicalIF":0.5000,"publicationDate":"2014-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1949095X.2015.1107176","citationCount":"22","resultStr":"{\"title\":\"Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity.\",\"authors\":\"Maria Moccia, Mauro F A Adamo, Michele Saviano\",\"doi\":\"10.1080/1949095X.2015.1107176\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>PNAs are emerging as useful synthetic devices targeting natural miRNAs. In particular 3 classes of structurally modified PNAs analogs are herein described, namely α, β and γ, which differ by their backbone modification. Their mode and binding affinity for natural nucleic acids and their use in medicinal chemistry as potential miRNA binders is discussed. </p>\",\"PeriodicalId\":50838,\"journal\":{\"name\":\"Agricultural History\",\"volume\":\"1 1\",\"pages\":\"e1107176\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2014-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/1949095X.2015.1107176\",\"citationCount\":\"22\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Agricultural History\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/1949095X.2015.1107176\",\"RegionNum\":3,\"RegionCategory\":\"哲学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2016/1/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"HISTORY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Agricultural History","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/1949095X.2015.1107176","RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/1/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"HISTORY","Score":null,"Total":0}
Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity.
PNAs are emerging as useful synthetic devices targeting natural miRNAs. In particular 3 classes of structurally modified PNAs analogs are herein described, namely α, β and γ, which differ by their backbone modification. Their mode and binding affinity for natural nucleic acids and their use in medicinal chemistry as potential miRNA binders is discussed.
期刊介绍：
Agricultural History is the journal of record in the field. As such, it publishes articles on all aspects of the history of agriculture and rural life with no geographical or temporal limits. The editors are particularly interested in articles that address a novel subject, demonstrate considerable primary and secondary research, display an original interpretation, and are of general interest to Society members and other Agricultural History readers.
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