硫化钠促进2-氨基苯甲酰胺和苯甲醇与单质硫的反应:2-芳基喹唑啉-4(3h)的新方法

Oanh Doan Thi Yen, Binh Vo Ngoc, Anh Ngo Quoc
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引用次数: 0

摘要

以S8\DMSO为氧化剂,以Na2S为促进剂,以2-氨基苯甲酰胺和苯甲醇为原料合成2-芳基- 4(3H)-喹唑啉酮衍生物。5H2O已被报道。合成了5个2-芳基-4(3H)-喹唑啉酮衍生物,产率为23% ~ 86%。
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SODIUM SULFIDE-PROMOTED REACTION OF 2-AMINOBENZAMIDE AND BENZYL ALCOHOLS WITH ELEMENTAL SULFUR: A NOVEL APPROACH WITH 2-ARYL-QUINAZOLIN-4(3H)
A simple metal- and solvent-free method for the synthesis of 2-aryl- 4(3H)-quinazolinone derivatives from 2-aminobenzamide and benzyl alcohols in the presence of S8\DMSO as an oxidizing agent and promoted by Na2S.5H2O has been reported. Five 2-aryl-4(3H)-quinazolinone derivatives were synthesized with yields from 23% to 86%.
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