腹泻是严重COVID-19的预后因素

Dinda Nisrina, H. Maulahela
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引用次数: 0

摘要

2020年3月,世界卫生组织宣布从中国武汉市开始的COVID-19进入大流行状态。病例的广泛传播导致印度尼西亚报告了2,877,476例病例和73,582例死亡。人们普遍认为,新冠肺炎的主要问题是呼吸系统,但最近有报道称,胃肠道的感染更有可能发展成严重病例。此外,腹泻是COVID-19患者中最常见的胃肠道体征和症状。本循证病例报告的目的是了解腹泻与COVID-19重症病例之间的关系。通过对Pubmed、Scopus和Cochrane的检索,得到5篇文章,使用循证医学中心(CEBM)关键评估工具进行评估。Ghimere S等人(2020)的最新系统评价发现,患有腹泻的COVID-19患者发展为重症病例的可能性更高(OR = 1.63, 95% CI: 1.11 - 2.38)。虽然队列研究显示了几个可能影响严重COVID-19病例结果的预后因素。由此可见,以腹泻为表现的患者更容易出现重症病例。因此,应仔细评估确诊的COVID-19腹泻患者,以预测症状恶化。
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Diarrhea as a Prognostic Factor for Severe COVID-19
In March of 2020, the WHO has declared the state pandemic of COVID-19 that started in the city of Wuhan, China. The widespread of cases resulted in 2,877,476 cases and 73,582 death reported in Indonesia. It is commonly known that the respiratory system was the main problem in COVID-19, but it is recently reported that gastrointestinal involevment has a higher likelihood to develop into severe cases. Moreover, it is found that diarrhea is the most highly prevalent of the gastrointestinal signs and symptoms in COVID-19 patients. The aim of this evidence-based case report is to understand the association between diarrhea and severe cases of COVID-19. A search on Pubmed, Scopus and Cochrane result in five articles to be appraised using Centre for Evidence-Based Medicine (CEBM) critical appraisal tool. The most recent systematic review by Ghimere S et al (2020), found COVID-19 patients with diarrhea has higher likelihood of developin ginto a severe case (OR = 1.63, 95% CI: 1.11 – 2.38). While the cohort studies showed several prognostic factors that may potentially effect the outcome of severe COVID-19 cases. It is concluded that severe COVID-19 cases were more likely to be found in patients presenting with diarrhea. Thus, Confirmed COVID-19 patients with diarrhea should be carefully evaluated to anticipate worsening of symptoms.
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