Evaluation of Anti-diabetic and Anti-oxidant Activity of Centratherum anthelmintica in STZ – induced Diabetic Rats

The present work is carried out to study the effect of Centratherum anthelminticum wild. kuntze (Asteaceae) on blood glucose level and antioxidant enzymes level in streptozotocin induced diabetic rats. Streptozotocin (STZ 50 mg/kg, i.p) induced diabetic rats were treated with methanolic extract of Centratherum anthelminticum (100 mg/kg; p.o.) for 28 days. Methanolic extract of Centratherum anthelminticum wild. Kuntze significantly prevented loss of body weight, decrease food and water intake. It showed significant prevention in elevation of glucose and significantly increased insulin level and showed prevention in increase in the cholesterol, triglyceride, LDL cholesterol, VLDL cholesterol levels in serum of diabetic rats. The treatment with methanolic extract of Centratherum anthelminticum also significantly prevented decrease in the HDL-cholesterol level and increase in urea and creatinine levels in diabetic rats compared to that of diabetic control. The chronic treatments with methanolic extract of CA significantly prevented the increase of malondialdehyde and prevent reduction of superoxide dismutase, catalase, and reduced glutathione levels. Histopathological study revealed that Centratherum anthelminticum extract provided significant protection against STZ induced degeneration in liver and kidney. This confirms the antidiabetic and antioxidant activity of Centratherum anthelminticum wild. kuntze in streptozotocin induced diabetic rats.