皮肤蠕虫病和代谢紊乱

E. Hristozov, K. Peeva, Valeri N. Malev, I. Yordanova, G. Mateev
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摘要

皮肤蠕虫病(CD)是一种毛囊皮脂腺单位疾病,临床上与其他面部皮肤病重叠,主要是酒渣鼻和痤疮。它通常通过杀螨单药治疗得到改善。本研究探讨了乳糜泻与代谢紊乱的关系。该研究对141例原发性和继发性CD患者进行了研究,研究了基于总胆固醇(TC)和低密度脂蛋白(LDL)紊乱的CD与血脂异常之间的关系,以及CD与糖耐量受损之间的关系,诊断为空腹血糖水平升高,口服糖耐量试验(OGTT) 120分钟血糖水平和数学计算的胰岛素抵抗稳态模型评估(HOMA-IR)指数。研究结果与对照组进行了验证。与对照组相比,乳糜泻患者血清脂蛋白没有统计学上的显著差异。然而,与对照组相比,乳糜泻患者倾向于糖耐量受损,表现为空腹血糖水平升高和HOMA-IR升高。有趣的是,糖尿病前期和糖尿病的倾向并没有被OGTT的120分钟血糖水平所证实。目前的数据证实有必要在每一个皮肤蠕虫病患者中检测糖耐量受损。根据现有证据,建议通过评估空腹血糖水平和空腹胰岛素水平进行筛查,然后计算HOMA-IR指数。
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Demodicosis Cutis and Metabolic Disturbances
Summary Cutaneous demodicosis (CD) is a pilosebaceous unit disease, overlapping clinically with other facial dermatoses, mainly rosacea, and acne. It is usually improved by acaricidal monotherapy. This study investigates the association of CD with metabolic disturbances. It was conducted with 141 patients with primary and secondary CD. The study investigated the correlation between CD and dyslipidemia based on disturbances in total cholesterol (TC) and Low-Density Lipoproteins (LDL) and between CD and impaired glucose tolerance, diagnosed with elevated fasting blood sugar levels, 120 minutes blood sugar levels in oral glucose tolerance test (OGTT) and the mathematically calculated Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index. The study results were verified with control groups. It was established that patients with CD do not show statistically significant deviations in serum lipoproteins compared with the control group. However, the patients with CD tended to have impaired glucose tolerance, demonstrated with elevated fasting glucose levels and elevated HOMA-IR, compared to the control group. Interestingly enough, the tendency towards prediabetes and diabetes was not confirmed by the 120 minutes blood glucose levels of the OGTT. The presented data confirm the need for testing impaired glucose tolerance in every patient with cutaneous demodicosis. Based on the presented evidence, it is recommended to perform the screening by evaluating fasting glucose levels and fasting insulin levels, followed by calculating the HOMA-IR index.
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