O. Maioru, L. Pop, V. Rădoi, R. Ursu, N. Bacalbaşa, I. Bălescu, Ioan Dumitru Suciu
{"title":"乳腺癌中的CHEK2基因","authors":"O. Maioru, L. Pop, V. Rădoi, R. Ursu, N. Bacalbaşa, I. Bălescu, Ioan Dumitru Suciu","doi":"10.37897/rmj.2022.s3.4","DOIUrl":null,"url":null,"abstract":"Checkpoint kinases (Chks) are serine/threonine kinases that are involved in the control of the cell cycle. Two subtypes have so far been identified, Chk1 and Chk2. They are essential components to delay cell cycle progression in all cells and act at all three cell cycle checkpoints. Here we provide more information regarding the CHEK2 gene and its role in breast cancer as well as known mutations that present a higher cancer risk.","PeriodicalId":21278,"journal":{"name":"Romanian Medical Journal","volume":"71 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CHEK2 gene in breast cancer\",\"authors\":\"O. Maioru, L. Pop, V. Rădoi, R. Ursu, N. Bacalbaşa, I. Bălescu, Ioan Dumitru Suciu\",\"doi\":\"10.37897/rmj.2022.s3.4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Checkpoint kinases (Chks) are serine/threonine kinases that are involved in the control of the cell cycle. Two subtypes have so far been identified, Chk1 and Chk2. They are essential components to delay cell cycle progression in all cells and act at all three cell cycle checkpoints. Here we provide more information regarding the CHEK2 gene and its role in breast cancer as well as known mutations that present a higher cancer risk.\",\"PeriodicalId\":21278,\"journal\":{\"name\":\"Romanian Medical Journal\",\"volume\":\"71 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Romanian Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37897/rmj.2022.s3.4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37897/rmj.2022.s3.4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Checkpoint kinases (Chks) are serine/threonine kinases that are involved in the control of the cell cycle. Two subtypes have so far been identified, Chk1 and Chk2. They are essential components to delay cell cycle progression in all cells and act at all three cell cycle checkpoints. Here we provide more information regarding the CHEK2 gene and its role in breast cancer as well as known mutations that present a higher cancer risk.
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