{"title":"综述了卡托普利胃保留漂浮片的天然高分子材料与合成高分子材料，并比较了高分子材料的疗效","authors":"S. Chauhan","doi":"10.20959/WJPR201711-9561","DOIUrl":null,"url":null,"abstract":"The oral route of drug administration is the most important method of administering drug for systematic effect. The present study was undertaken to prolong the release of orally administer. Captopril in the floating tablets by using different grade of HPMC. Formulation were optimized using different viscosity grades of HPMC. Lactose and citric acid and also natural polymers chitosan and carbopole. were used in different concentration as a channeling and chelating agent to obtain best optimized formulation and designed to prolong the gastric residence time (GRT). KEYWORD: gastroretentive floating drung delivery system, Gastric retention time, HPMC, Lactose, Carbopole, Chitosan.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"28 1","pages":"796-817"},"PeriodicalIF":0.0000,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A COMPREHENSIVE REVIEW ON GASTRORETENTIVE FLOATING TABLET OF CAPTOPRIL USING NATURAL AND SYNTHETIC POLYMER WITH COMPARISION OF POLYMER EFFICACY\",\"authors\":\"S. Chauhan\",\"doi\":\"10.20959/WJPR201711-9561\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The oral route of drug administration is the most important method of administering drug for systematic effect. The present study was undertaken to prolong the release of orally administer. Captopril in the floating tablets by using different grade of HPMC. Formulation were optimized using different viscosity grades of HPMC. Lactose and citric acid and also natural polymers chitosan and carbopole. were used in different concentration as a channeling and chelating agent to obtain best optimized formulation and designed to prolong the gastric residence time (GRT). KEYWORD: gastroretentive floating drung delivery system, Gastric retention time, HPMC, Lactose, Carbopole, Chitosan.\",\"PeriodicalId\":23796,\"journal\":{\"name\":\"World journal of pharmaceutical research\",\"volume\":\"28 1\",\"pages\":\"796-817\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal of pharmaceutical research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20959/WJPR201711-9561\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of pharmaceutical research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20959/WJPR201711-9561","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A COMPREHENSIVE REVIEW ON GASTRORETENTIVE FLOATING TABLET OF CAPTOPRIL USING NATURAL AND SYNTHETIC POLYMER WITH COMPARISION OF POLYMER EFFICACY
The oral route of drug administration is the most important method of administering drug for systematic effect. The present study was undertaken to prolong the release of orally administer. Captopril in the floating tablets by using different grade of HPMC. Formulation were optimized using different viscosity grades of HPMC. Lactose and citric acid and also natural polymers chitosan and carbopole. were used in different concentration as a channeling and chelating agent to obtain best optimized formulation and designed to prolong the gastric residence time (GRT). KEYWORD: gastroretentive floating drung delivery system, Gastric retention time, HPMC, Lactose, Carbopole, Chitosan.
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