{"title":"坦桑尼亚一些特有植物提取物的抗癌活性研究","authors":"C. Nshimo, A. Kamuhabwa, Z. Mbwambo, P. Witte","doi":"10.4314/ECAJPS.V10I3.9765","DOIUrl":null,"url":null,"abstract":"Plants have shown to be good sources of a variety of drugs for human ailments including cancer. Tanzania is rich in plant species most of which have not been investigated for any biological activity. In the continuing effort to screen Tanzanian plants for anticancer activity, plants were collected from Lindi region and extracts tested for the activity using two cell lines namely RT112 (Human bladder transitional cell carcinoma) and HeLa (Human cervical carcinoma). Of the 52 extracts from 26 plants of different families tested, 5 demonstrated potential activity on the cells. Extract X13 had an exceptionally high activity on both cell lines while extract X29 was highly active on HeLa cells. Fractionation and isolation of constituents from the extracts that have shown anticancer activity in these cell lines is recommended. Keywords : Medicinal plants, extracts, anticancer activity, screening East and Central African Journal of Pharmaceutical Sciences Vol. 10 (3) 2007: pp. 63-67","PeriodicalId":22387,"journal":{"name":"The East and Central African Journal of Pharmaceutical Sciences","volume":"15 1","pages":"63-67"},"PeriodicalIF":0.0000,"publicationDate":"2008-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Anticancer Activity of Extracts from some Endemic Tanzanian Plants\",\"authors\":\"C. Nshimo, A. Kamuhabwa, Z. Mbwambo, P. Witte\",\"doi\":\"10.4314/ECAJPS.V10I3.9765\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Plants have shown to be good sources of a variety of drugs for human ailments including cancer. Tanzania is rich in plant species most of which have not been investigated for any biological activity. In the continuing effort to screen Tanzanian plants for anticancer activity, plants were collected from Lindi region and extracts tested for the activity using two cell lines namely RT112 (Human bladder transitional cell carcinoma) and HeLa (Human cervical carcinoma). Of the 52 extracts from 26 plants of different families tested, 5 demonstrated potential activity on the cells. Extract X13 had an exceptionally high activity on both cell lines while extract X29 was highly active on HeLa cells. Fractionation and isolation of constituents from the extracts that have shown anticancer activity in these cell lines is recommended. Keywords : Medicinal plants, extracts, anticancer activity, screening East and Central African Journal of Pharmaceutical Sciences Vol. 10 (3) 2007: pp. 63-67\",\"PeriodicalId\":22387,\"journal\":{\"name\":\"The East and Central African Journal of Pharmaceutical Sciences\",\"volume\":\"15 1\",\"pages\":\"63-67\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The East and Central African Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/ECAJPS.V10I3.9765\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The East and Central African Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ECAJPS.V10I3.9765","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
植物已被证明是治疗包括癌症在内的人类疾病的多种药物的良好来源。坦桑尼亚拥有丰富的植物物种，其中大多数尚未对其生物活性进行过调查。为了继续筛选坦桑尼亚植物的抗癌活性，我们收集了来自林迪地区的植物，并使用两种细胞系RT112(人膀胱移行细胞癌)和HeLa(人宫颈癌)对其提取物进行了活性测试。在26个不同科植物的52种提取物中，有5种对细胞有潜在的活性。提取物X13对两种细胞系均有较高的活性，而提取物X29对HeLa细胞有较高的活性。建议从提取物中分离出具有抗癌活性的成分。关键词:药用植物，提取物，抗癌活性，筛选东非和中非药物科学杂志Vol. 10 (3) 2007: pp. 63-67
Anticancer Activity of Extracts from some Endemic Tanzanian Plants
Plants have shown to be good sources of a variety of drugs for human ailments including cancer. Tanzania is rich in plant species most of which have not been investigated for any biological activity. In the continuing effort to screen Tanzanian plants for anticancer activity, plants were collected from Lindi region and extracts tested for the activity using two cell lines namely RT112 (Human bladder transitional cell carcinoma) and HeLa (Human cervical carcinoma). Of the 52 extracts from 26 plants of different families tested, 5 demonstrated potential activity on the cells. Extract X13 had an exceptionally high activity on both cell lines while extract X29 was highly active on HeLa cells. Fractionation and isolation of constituents from the extracts that have shown anticancer activity in these cell lines is recommended. Keywords : Medicinal plants, extracts, anticancer activity, screening East and Central African Journal of Pharmaceutical Sciences Vol. 10 (3) 2007: pp. 63-67
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