{"title":"肝移植术后急性肝功能衰竭患者的生存分析","authors":"Xingqiang Wang, Yi-he Liu, Li-xin Yu, Yan Sun","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.11.007","DOIUrl":null,"url":null,"abstract":"Objective \nTo explore the clinical efficacy and risk factors of mortality for liver transplantation in patients with acute liver failure. \n \n \nMethods \nFrom January 2012 to December 2017, retrospective analysis was performed for 31 patients with acute liver failure undergoing orthotopic liver transplantation. Clinical data and follow-up data were recorded. Univariate survival analysis was performed by Kaplan-Meier and Log-rank tests while multivariate survival analysis conducted by proportional hazards model. \n \n \nResults \nAge ≥55 years, preoperative hepatorenal syndrome, perioperative infection and preoperative non-molecular adsorbent recirculating system (MARS) support were influencing factors of postoperative survival rate by univariate survival analysis (P<0.05). Preoperative infection was an independent risk factor for survival after liver transplantation by multivariate COX regression analysis (P<0.01). \n \n \nConclusions \nLiver transplantation is an effective treatment for acute liver failure. And preoperative infection is an independent risk factor for survival after liver transplantation. \n \n \nKey words: \nLiver failure; Acute; Liver transplantation; Survival analysis","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Survival analysis of patients with acute liver failure after liver transplantation\",\"authors\":\"Xingqiang Wang, Yi-he Liu, Li-xin Yu, Yan Sun\",\"doi\":\"10.3760/CMA.J.ISSN.0254-1785.2019.11.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo explore the clinical efficacy and risk factors of mortality for liver transplantation in patients with acute liver failure. \\n \\n \\nMethods \\nFrom January 2012 to December 2017, retrospective analysis was performed for 31 patients with acute liver failure undergoing orthotopic liver transplantation. Clinical data and follow-up data were recorded. Univariate survival analysis was performed by Kaplan-Meier and Log-rank tests while multivariate survival analysis conducted by proportional hazards model. \\n \\n \\nResults \\nAge ≥55 years, preoperative hepatorenal syndrome, perioperative infection and preoperative non-molecular adsorbent recirculating system (MARS) support were influencing factors of postoperative survival rate by univariate survival analysis (P<0.05). Preoperative infection was an independent risk factor for survival after liver transplantation by multivariate COX regression analysis (P<0.01). \\n \\n \\nConclusions \\nLiver transplantation is an effective treatment for acute liver failure. And preoperative infection is an independent risk factor for survival after liver transplantation. \\n \\n \\nKey words: \\nLiver failure; Acute; Liver transplantation; Survival analysis\",\"PeriodicalId\":9885,\"journal\":{\"name\":\"Chineae Journal of Organ Transplantation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chineae Journal of Organ Transplantation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.11.007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chineae Journal of Organ Transplantation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.11.007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Survival analysis of patients with acute liver failure after liver transplantation
Objective
To explore the clinical efficacy and risk factors of mortality for liver transplantation in patients with acute liver failure.
Methods
From January 2012 to December 2017, retrospective analysis was performed for 31 patients with acute liver failure undergoing orthotopic liver transplantation. Clinical data and follow-up data were recorded. Univariate survival analysis was performed by Kaplan-Meier and Log-rank tests while multivariate survival analysis conducted by proportional hazards model.
Results
Age ≥55 years, preoperative hepatorenal syndrome, perioperative infection and preoperative non-molecular adsorbent recirculating system (MARS) support were influencing factors of postoperative survival rate by univariate survival analysis (P<0.05). Preoperative infection was an independent risk factor for survival after liver transplantation by multivariate COX regression analysis (P<0.01).
Conclusions
Liver transplantation is an effective treatment for acute liver failure. And preoperative infection is an independent risk factor for survival after liver transplantation.
Key words:
Liver failure; Acute; Liver transplantation; Survival analysis
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