ABSENCE OF VISIBLE TOXIC EFFECTS ACCOMPANYING THE SHORT-TERM ADMINISTRATION OF AN AQUEOUS EXTRACT OF ALLIUM SATIVA LINN. IN MALE SPRAGUE-DAWLEY RATS

Allium sativum is cultivated in the northern part of Ghana and has gained widespread use as chemoprotective, in curing hypertension, impotence and erectile dysfunction. The multipurpose use together with its aphrodisiac activity has resulted in the widespread use of this plant medicine both in meals and as herbal medications. Safety assessment of this plant however is rare. The present study is designed to evaluate the toxic effect of the aqueous extract of Allium sativa on the prostate, heart, liver kidney and haematological parameters after a shorterm administration in male-sprague-dawley rats. The following doses were used in different groups of male Sprague-Dawley Rats: 5000, 3000 and 1000 mg kg-1. The following parameters were monitored: Clinical Chemistry, Gross and Histopathology (Heart, kidney, liver and prostate). No death was recorded at the highest dose of 5000 mg kg-1. ASE reduced levels of urea and creatinine but increased levels of liver enzymes ALT, AST, ALP and bilirubin levels as compared to the controls. There was a statistically significant increase in WBC count (p