手术治疗T4结直肠癌腹膜癌154例分析

Wei Chen, Junwen Ye, Xiao-ping Tan, Yan Zhang, Jing-lin Liang, Mei-jin Huang
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引用次数: 0

摘要

目的:本研究的目的是观察T4患者行结直肠癌合并腹膜癌手术的相关因素。方法:选取1994年8月至2005年12月中山大学附属第一医院行手术治疗的154例T4结直肠癌患者为研究对象。选择一些临床变量与预后有统计学相关性。结果:2010年12月底总生存时间为91.7个月或死亡。与姑息性手术组相比,完全细胞减少组有显著的生存优势。单因素分析显示,年龄、部位、组织学分级、完全细胞减少和肝转移与总生存时间(OS)相关(P < 0.05)。此外,Cox多因素分析显示,完全细胞减少(complete cytoreduction, CCR)和肝转移是影响生存的独立因素。结论:与姑息性手术相比,不完全细胞减少术不能改善患者预后。完成细胞减少术的患者预后相对较好。
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Analysis of 154 T4 Colorectal Cancer Patients with Peritoneal Carcinomatosis Treated by Surgery
Objective: The purpose of this study was to observe the factors related to T4 patients who underwent surgery for colorectal cancer (CRC) with peritoneal carcinomatosis. Methods: 154 T4 colorectal cancer patients who underwent surgery in the first Affiliated Hospital of Sun Yat-sen University were included in the study between August, 1994 and December, 2005. Some clinical variables were selected and statistically correlated with prognosis. Results: The overall survival time was 91.7 months at the end of December of 2010 or death. The complete cytoreduction had significant survival benefit than the palliative surgery group. The age, location, histological grade, complete cytoreduction and liver metastasis were associated with overall survival time (OS) according to the univariate analysis (P < 0.05). In addition, Cox multivariate analysis showed that the complete cytoreduction (CCR) and liver metastasis were independent factor influencing survival. Conclusion: Compared with palliative surgery, the incomplete cytoreduction fails to improve patient prognosis. Patients performed completed cytoreduction have a relative good prognosis.
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