{"title":"抗真菌药物替布康唑复合毒性作用对大鼠脑组织胆碱能系统的影响","authors":"A. ÇİLİNGİR YELTEKİN","doi":"10.3153/ar22010","DOIUrl":null,"url":null,"abstract":"Today, fungicide toxicity is quite common in aquatic ecosystems, and this situation adversely affects marine organisms. For this reason, it is essential to determine the effects of fungicides on aquatic organisms and to try to prevent organisms from being exposed to these toxic chemicals. In this study, changes in cholinergic system enzymes and (malondialdehyde) MDA levels as a result of exposure to acute fungicide toxicity in Van fish (Alburnus tarichi, Güldenstädt 1814) were investigated. Brain tissue was taken from Van fish exposed to 2.5 M Tebuconazole used in agriculture by sampling at 24, 48, 72, and 96 hours. Brain tissue acetylcholinesterase (AChE), butyrylcholinesterase (BChE) activities, and MDA levels were measured in this context. In the study, AChE (0.965 ±0.03, 0.575±0.01) and BChE (0.421 ±0.02, 0,291 ±0.01) activities decreased in Van fish brain tissue due to exposure to Tebuconazole, but MDA (0.099 ±0.01, 0.192 ±0.01) level increased (p < 0.05).","PeriodicalId":13619,"journal":{"name":"International Aquatic Research","volume":"236 1","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity\",\"authors\":\"A. ÇİLİNGİR YELTEKİN\",\"doi\":\"10.3153/ar22010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Today, fungicide toxicity is quite common in aquatic ecosystems, and this situation adversely affects marine organisms. For this reason, it is essential to determine the effects of fungicides on aquatic organisms and to try to prevent organisms from being exposed to these toxic chemicals. In this study, changes in cholinergic system enzymes and (malondialdehyde) MDA levels as a result of exposure to acute fungicide toxicity in Van fish (Alburnus tarichi, Güldenstädt 1814) were investigated. Brain tissue was taken from Van fish exposed to 2.5 M Tebuconazole used in agriculture by sampling at 24, 48, 72, and 96 hours. Brain tissue acetylcholinesterase (AChE), butyrylcholinesterase (BChE) activities, and MDA levels were measured in this context. In the study, AChE (0.965 ±0.03, 0.575±0.01) and BChE (0.421 ±0.02, 0,291 ±0.01) activities decreased in Van fish brain tissue due to exposure to Tebuconazole, but MDA (0.099 ±0.01, 0.192 ±0.01) level increased (p < 0.05).\",\"PeriodicalId\":13619,\"journal\":{\"name\":\"International Aquatic Research\",\"volume\":\"236 1\",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Aquatic Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3153/ar22010\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MARINE & FRESHWATER BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Aquatic Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3153/ar22010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MARINE & FRESHWATER BIOLOGY","Score":null,"Total":0}
The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity
Today, fungicide toxicity is quite common in aquatic ecosystems, and this situation adversely affects marine organisms. For this reason, it is essential to determine the effects of fungicides on aquatic organisms and to try to prevent organisms from being exposed to these toxic chemicals. In this study, changes in cholinergic system enzymes and (malondialdehyde) MDA levels as a result of exposure to acute fungicide toxicity in Van fish (Alburnus tarichi, Güldenstädt 1814) were investigated. Brain tissue was taken from Van fish exposed to 2.5 M Tebuconazole used in agriculture by sampling at 24, 48, 72, and 96 hours. Brain tissue acetylcholinesterase (AChE), butyrylcholinesterase (BChE) activities, and MDA levels were measured in this context. In the study, AChE (0.965 ±0.03, 0.575±0.01) and BChE (0.421 ±0.02, 0,291 ±0.01) activities decreased in Van fish brain tissue due to exposure to Tebuconazole, but MDA (0.099 ±0.01, 0.192 ±0.01) level increased (p < 0.05).
期刊介绍：
The journal (IAR) is an international journal that publishes original research articles, short communications, and review articles in a broad range of areas relevant to all aspects of aquatic sciences (freshwater and marine). The Journal specifically strives to increase the knowledge of most aspects of applied researches in both cultivated and wild aquatic animals in the world. The journal is fully sponsored, which means it is free of charge for authors. The journal operates a single-blind peer review process. The main research areas in aquatic sciences include: -Aquaculture- Ecology- Food science and technology- Molecular biology- Nutrition- Physiology- Water quality- Climate Change
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