骨肉瘤的流行病学:印度尼西亚的单中心研究

David Kalim, Andriandi
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摘要

目的了解哈吉亚当马利克总医院骨肉瘤流行病学。材料与方法本研究是一项采用横断面方法的回顾性描述性研究。2012年1月至2017年12月期间在哈吉亚当马利克医院就诊的肌肉骨骼肿瘤(尤其是骨肉瘤)患者,从病历中记录其年龄、性别、肌肉骨骼肿瘤类型、活检结果、肿瘤部位、治疗完成情况、转移情况和截肢情况。结果原发性骨肿瘤最多,占肌肉骨骼肿瘤的50%,其次是软组织肿瘤和转移性骨病。男性(60%)的患病率略高于女性(40%)。原发性骨肿瘤发病率前三位为骨肉瘤、骨肉瘤、骨软骨瘤,分别为63%、13%和6%。特别是骨肉瘤,男女患病率比为1.9:1。骨肉瘤最常见的部位是股骨远端(45%)和胫骨近端(29%)。约63%的患者接受了完整的治疗,55%的患者在首次诊断时发生了转移,89%的患者进行了截肢。结论原发性骨肿瘤占主导地位,肌肉骨骼肿瘤占50%,其次是软组织肿瘤占31%,转移性骨病占19%。肌肉骨骼肿瘤的发病率显示,男性在60%和40%上略高于女性。原发性骨肿瘤发病率前三位为骨肉瘤、巨细胞瘤和骨软骨瘤,分别为63%、13%和6%。
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Epidemiology of Osteosarcoma : Single Center Study in Indonesia
ObjectiveTo assess osteosarcoma epidemiology in Haji Adam Malik General Hospital. Material and MethodsThis study is a retrospective descriptive study with a crosssectional approach. Patient with musculoskeletal tumour (especially osteosarcoma) in Haji Adam Malik Hospital from January 2012 to Desember 2017 period, got their age, gender, musculoskeletal tumour type, biopsy result, tumour sites, treatment completion, metastasis and amputation status recorded from their medical record. Result-Primary bone tumors is the most cases and found in 50% of musculoskeletal tumors followed by soft tissue tumors and metastatic bone disease. Male (60%) have slightly higher prevalence than female in (40%). The incidence of primary bone tumors shows osteosarcoma, GCT, and osteochondroma are in the top three with 63%, 13%, and 6% respectively. Specifically for osteosarcoma, male and female have 1.9 : 1 prevalence ratio. The most common sites for osteosarcoma is distal the femur (45%) and proximal tibia (29%). About 63% of patients undergo complete treatment and with 55% recorded with metastasis in the first diagnosis and amputation was performed in 89% of patients. ConclusionPrimary bone tumors dominate the data with 50% for musculoskeletal tumors followed by 31% soft tissue tumors and 19% metastatic bone disease. The incidence of musculoskeletal tumors shows that men are slightly higher than women in 60% and 40%. The incidence of primary bone tumors shows osteosarcoma, giant cell tumor, and osteochondroma are in the top three with 63%, 13%, and 6% respectively.
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