在热带环境中使用三氯生作为抗菌剂的消费品:安全还是不安全?

Maiwada As, B. Abdulkadir
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引用次数: 0

摘要

世界上的热带环境全年接受最高的太阳辐射,年平均温度不低于180℃。在牙膏、漱口水、肥皂、腋下除臭剂、洗洁精和家用设备(如纺织材料)中使用三氯生作为抗菌剂,在过去几十年里,这种环境中的玩具和塑料厨具呈指数级增长,其在强烈的太阳辐射和焚烧下形成低氯二恶英(多氯二苯并二恶英和多氯二苯并呋喃)的能力对人类健康和水生环境构成了巨大的潜在风险。本文旨在提高公众对使用含三氯生材料的潜在相关风险及其对人类健康和水生环境可能产生的影响的认识。人类和水生动物通过口腔、皮肤、吸入和意外的眼部接触接触三氯生。在美国、英国、加拿大和澳大利亚等许多温带发达国家,对三氯生及其对人类健康和水生环境的相关风险进行了风险评估,尽管在人体体液和水生动物组织中存在三氯生的痕迹,但得出的结论是,进入环境的三氯生不会对人类和水生生物构成威胁。这一结论存在很多不确定性和保守性,特别是由于缺乏足够的数据来充分表征三氯生暴露在一般人群中的代表性、所有年龄组的尿样剂量估计和转换、暴露边际(MOEs)的充分性以及地方之间的空间差异。此外,强烈建议对三氯生及其影响人类健康和水生环境的可能性进行深入研究,特别是在发展中热带国家,以便提高公众的认识。
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Consumer Products using Triclosan as Antimicrobial Agent in the Tropical Environment: Safe or Unsafe?
The tropical environments of the world receive the highest solar radiation throughout the year with an average annual temperature of not less than 180°C. The use of triclosan as an antimicrobial agent in consumer products such as toothpastes, mouthwash, soaps, under arm deodorants, liquid dishwashing soap and household equipment like textiles materials, toys and plastic kitchenware in this environment exponentially increased over the last few decades and its ability to form low chlorinated dioxins (polychlorinated dibenzodioxins and polychlorinated dibenzofurans) on intense solar radiation and incineration has posed a great risk potential to human health and the aquatic environments. This article aimed to create awareness to the general public on the potentially associated risks of using Triclosan containing materials and its possible implications on human health and the aquatic environments. Humans and aquatic animals get in contact with triclosan through oral, dermal, inhalation and accidental ocular exposures. In many temperate developed countries like US, UK, Canada and Australia, risk assessments was conducted on triclosan and its associated risks to Human health and aquatic environment, despites its traces in human body fluids and aquatic animal tissues, it is concluded that triclosan entering the environment in a way that poses no threat to humanity and aquatic lives. This conclusion came up with lots of uncertainties and conservatism especially due to a lack of adequate data to fully characterize the exposure to triclosan for the representation of the general population, dose estimation and conversion of spot urine samples for all age groups, adequacy of the margin of exposure (MOEs) and spatial differences between places. Moreover, indepth research on triclosan and its potentialities to affect human health and the aquatic environment is strongly recommended especially in the developing tropical countries in order to create awareness to the general public.
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