The expression pattern of anti-glycosaminoglycan in skin aging in human

Maryam Majid Eshaq and May F. Al-Habib B.Sc, Biology, College of science, Baghdad University, Iraq Ph.D, Histology and Embryology, College of Medicine, AL-Nahrain University, Iraq Corresponding author: Maryam Majid Eshaq, Email: merriamallos@gmail.com Abstract Aging of the skin is the most visible and obvious sign of living individual and it is complex phenomenon caused by harmful factors. Intrinsic aging (chronological aging) and extrinsic aging (photoaging) are major factors leading to revers effects on skin. Glycosaminoglycan (GAGs) are long blocks of negatively charged polysaccharides, they are one of the major components of the extracellular matrix. Anti-glycosaminoglycan expression shows a high expression reaction in group (A) with a mean value (0.427 pixel /μ2) the intensity of the reaction are represented in the stratum corneum, basement membrane and highly in the dermal matrix. The intensity of reaction is beginning to decrease gradually in group (B) with a mean value (0.254 pixel /μ2) there is a highly significant differences between (A)&(B) group with a p-value (0.0001), while in group(C) the intensity of the reaction is strikingly decrease with a mean value (0.191 pixel /μ2) there is a highly significant differences between the (A)&(C) groups represented with pvalue (0.0001) in comparison with the (B)group the p-value is (0.002). From this study it is concluded that the expression of antiglycosaminoglycan shows different manner according to age. Being higher in young age and diminishing expression of Anti-GAGs was recorded with aging. There is a statistically significant difference in the expression of anti-GAGs between different age groups.