胃保留性给药系统综述:目前的方法和进展

Anupama Tomar, Aakash Upadhyay, S. Gupta, Shobhit Kumar
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引用次数: 10

摘要

胃保留性给药系统(GRDDS)通过在药物扩展吸收位点之前持续一段时间释放药物,从而提高具有吸收窗口的药物的可控递送。这包括漂浮系统、扩张系统、黏附系统、高密度系统和其他延迟胃排空装置。本文简要介绍了GRDDS的配方考虑、胃保留时间的控制因素、GRDDS的优缺点及评价。
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An Overview on Gastroretentive Drug Delivery System: Current Approaches and Advancements
Gastroretentive Drug Delivery System (GRDDS) can elevate the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a constant period of time before it extends its absorption site. This includes floating system, dilation and expanding system, muco - adhesive system, high density system and other postponed gastric emptying devices. The present article briefly about the formulation consideration for GRDDS, factors controlling gastric retention time, advantages, disadvantages and evaluation of GRDDS.
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