{"title":"青蒿素联合疗法;安全还是不安全?","authors":"U. Georgewill, O. Ebong","doi":"10.5580/2b58","DOIUrl":null,"url":null,"abstract":"This study evaluated the safety profile of five brands of Artemisinin Combination Therapies (ACTs); Dihydroartemisinin plus Piperaquine(DP), Artesunate plus Amodiaquine(AS+AQ), Artesunate plus Sulphadoxine/Pyrimethamine(AS+S/P), Artemether plus lumefantrine(AL) and Artesunate plus mefloquine(AS+MQ) combinations in mice. A total of 70 mice were used for the subacute toxicity test. The mice were placed in groups of five and received clinical and double clinical doses of the Artemether Combination Therapies(ACTs). The control groups received clinical and double clinical doses of chloroquine and water. Treatment was done once daily for seven days and on alternate days for twenty three days. On day 31, the animals were sacrificed and the liver, kidney and heart were harvested. Histological examination revealed no significant treatment related histopathological changes in the heart, liver and kidney of all the treated groups as the tissues showed normal cytoarchitecture comparable to that of the control. Our findings reveal that these drugs are relatively safe and the results could give some help to future researches.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"84 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2012-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Artemisinin Combination Therapies; Safe Or Not Safe ?\",\"authors\":\"U. Georgewill, O. Ebong\",\"doi\":\"10.5580/2b58\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study evaluated the safety profile of five brands of Artemisinin Combination Therapies (ACTs); Dihydroartemisinin plus Piperaquine(DP), Artesunate plus Amodiaquine(AS+AQ), Artesunate plus Sulphadoxine/Pyrimethamine(AS+S/P), Artemether plus lumefantrine(AL) and Artesunate plus mefloquine(AS+MQ) combinations in mice. A total of 70 mice were used for the subacute toxicity test. The mice were placed in groups of five and received clinical and double clinical doses of the Artemether Combination Therapies(ACTs). The control groups received clinical and double clinical doses of chloroquine and water. Treatment was done once daily for seven days and on alternate days for twenty three days. On day 31, the animals were sacrificed and the liver, kidney and heart were harvested. Histological examination revealed no significant treatment related histopathological changes in the heart, liver and kidney of all the treated groups as the tissues showed normal cytoarchitecture comparable to that of the control. Our findings reveal that these drugs are relatively safe and the results could give some help to future researches.\",\"PeriodicalId\":22523,\"journal\":{\"name\":\"The Internet Journal of Pharmacology\",\"volume\":\"84 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-01-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/2b58\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/2b58","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Artemisinin Combination Therapies; Safe Or Not Safe ?
This study evaluated the safety profile of five brands of Artemisinin Combination Therapies (ACTs); Dihydroartemisinin plus Piperaquine(DP), Artesunate plus Amodiaquine(AS+AQ), Artesunate plus Sulphadoxine/Pyrimethamine(AS+S/P), Artemether plus lumefantrine(AL) and Artesunate plus mefloquine(AS+MQ) combinations in mice. A total of 70 mice were used for the subacute toxicity test. The mice were placed in groups of five and received clinical and double clinical doses of the Artemether Combination Therapies(ACTs). The control groups received clinical and double clinical doses of chloroquine and water. Treatment was done once daily for seven days and on alternate days for twenty three days. On day 31, the animals were sacrificed and the liver, kidney and heart were harvested. Histological examination revealed no significant treatment related histopathological changes in the heart, liver and kidney of all the treated groups as the tissues showed normal cytoarchitecture comparable to that of the control. Our findings reveal that these drugs are relatively safe and the results could give some help to future researches.
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