INTERHEMISPHERIC BRAIN ASYMMETRY AND METABOLIC CHANGES IN RATS WITH DIFFERENT ALCOHOL MOTIVATION

The analysis of motor inter hemispheric asymmetry in rats differing in the degree of alcohol motivation and learnin gability at different stages of chronic alcoholization was performed. The qualitative and quantitative composition of blood lipids was determined as an integral indicator of the degree of ethanol influence on metabolic processes at different stages of chronic alcoholization. The obtained results indicate a certain right-hemispheric character of lateralization of the "alcohol dominant", since among alcohol-dependent rats, animals with left-sided motor a symme try were more common. In chronically alcoholic animals, the effect of alcohol on individual profiles of functional a symme try and changes in hemispheric dominance was found, which was manifested in the modulation of left motor a symme try profiles and inhibition of information processing in the righ the misp here. In addition, among rats with high learnin gability, there were significantly more animals with right-sided motor asymmetry. Chronic alcoholization led to an intensification of catabolic processes in the body, as evidenced by an increase in the concentration of triglycerides and free fatty acids in the blood of rats, which correlates with the formation of alcohol dependence. The increase in lipid concentration correlated with the stage of alcohol dependence formation.