Andrey V. Samoshin, I. Dotsenko, Nataliya M. Samoshina, A. Franz, V. Samoshin
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引用次数: 6
摘要
合成了结构简单的1-硫代-β- d -葡萄糖吡喃苷，并对米曲霉和癌变青霉的几种真菌糖苷酶进行了潜在的抑制剂测试。对α-和β-葡萄糖苷酶有明显的选择性抑制，而对α-和β-半乳糖糖苷酶有弱至中度的激活。
Thio-β-D-glucosides: Synthesis and Evaluation as Glycosidase Inhibitors and Activators
Structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors toward several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-glucosidases, while a weak to moderate activation for α- and β-galactosidases.
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