蛋白A超抗原:结构、工程和抗体识别的分子基础。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Protein Engineering Design & Selection Pub Date : 2019-12-31 DOI:10.1093/protein/gzz026

Ohan Mazigi, Peter Schofield, D. Langley, D. Christ

{"title":"蛋白A超抗原:结构、工程和抗体识别的分子基础。","authors":"Ohan Mazigi, Peter Schofield, D. Langley, D. Christ","doi":"10.1093/protein/gzz026","DOIUrl":null,"url":null,"abstract":"Staphylococcus aureus interacts with the human immune system through the production of secreted factors. Key among these is protein A, a B-cell superantigen capable of interacting with both antibody Fc and VH regions. Here, we review structural and molecular features of this important example of naturally occurring bacterial superantigens, as well as engineered variants and their application in biotechnology.","PeriodicalId":54543,"journal":{"name":"Protein Engineering Design & Selection","volume":"20 1","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":"{\"title\":\"Protein A superantigen: structure, engineering and molecular basis of antibody recognition.\",\"authors\":\"Ohan Mazigi, Peter Schofield, D. Langley, D. Christ\",\"doi\":\"10.1093/protein/gzz026\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Staphylococcus aureus interacts with the human immune system through the production of secreted factors. Key among these is protein A, a B-cell superantigen capable of interacting with both antibody Fc and VH regions. Here, we review structural and molecular features of this important example of naturally occurring bacterial superantigens, as well as engineered variants and their application in biotechnology.\",\"PeriodicalId\":54543,\"journal\":{\"name\":\"Protein Engineering Design & Selection\",\"volume\":\"20 1\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2019-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Protein Engineering Design & Selection\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1093/protein/gzz026\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Protein Engineering Design & Selection","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/protein/gzz026","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 10

摘要

金黄色葡萄球菌通过分泌因子与人体免疫系统相互作用。其中的关键是蛋白A，一种能够与抗体Fc和VH区相互作用的b细胞超抗原。在这里，我们回顾了这种重要的天然细菌超级抗原的结构和分子特征，以及工程变异体及其在生物技术中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Protein A superantigen: structure, engineering and molecular basis of antibody recognition.

Staphylococcus aureus interacts with the human immune system through the production of secreted factors. Key among these is protein A, a B-cell superantigen capable of interacting with both antibody Fc and VH regions. Here, we review structural and molecular features of this important example of naturally occurring bacterial superantigens, as well as engineered variants and their application in biotechnology.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Protein Engineering Design & Selection 生物-生化与分子生物学

CiteScore

3.30

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Protein Engineering, Design and Selection (PEDS) publishes high-quality research papers and review articles relevant to the engineering, design and selection of proteins for use in biotechnology and therapy, and for understanding the fundamental link between protein sequence, structure, dynamics, function, and evolution.