{"title":"免疫激活肽刺激脐带血单核细胞杀菌活性的研究","authors":"S. Ju, Byung-Sam Kim, Sang-Kyu Park","doi":"10.1109/KORUS.2000.865962","DOIUrl":null,"url":null,"abstract":"Seong-A Ju', Byung-Sam Kun', and Sang-Kyu Park2 Dept. of Biological Science, University of Ulsan, San-29 Moogu-2 Dong, Namgu, Ulsan 680-749, Korea and 2College of Medicine, University of Ulsan, Ulsan 682-060, Korea Tel: +82(52)2592393, Fax: +82(52)2591694 E-mail: Sang@uuh.ulsan.kr Abstract Mononuclear phagocytes play a central role in the host defense against infections. We report that synthetic novel peptide, WKYMVm which is In vivo tests, WKYMVm increase killing activities of monocytes against S. aureus. Rats were preinfected with S. aureus and treated with WKYMVm. The number of bacteria remaining on blood of WKYMVm-treated rats was rapidly decreased compare with control group. In vitro cell cultures, WKYMVm increase bactericidal and fungicidal activities of monocytes derived from adult human peripheral blood and neonatal cord blood. 1","PeriodicalId":20531,"journal":{"name":"Proceedings KORUS 2000. The 4th Korea-Russia International Symposium On Science and Technology","volume":"43 1","pages":"253-256"},"PeriodicalIF":0.0000,"publicationDate":"2000-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Stimulation of bactericidal activity of umbilical cord blood monocytes by immunoactivating peptide\",\"authors\":\"S. Ju, Byung-Sam Kim, Sang-Kyu Park\",\"doi\":\"10.1109/KORUS.2000.865962\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Seong-A Ju', Byung-Sam Kun', and Sang-Kyu Park2 Dept. of Biological Science, University of Ulsan, San-29 Moogu-2 Dong, Namgu, Ulsan 680-749, Korea and 2College of Medicine, University of Ulsan, Ulsan 682-060, Korea Tel: +82(52)2592393, Fax: +82(52)2591694 E-mail: Sang@uuh.ulsan.kr Abstract Mononuclear phagocytes play a central role in the host defense against infections. We report that synthetic novel peptide, WKYMVm which is In vivo tests, WKYMVm increase killing activities of monocytes against S. aureus. Rats were preinfected with S. aureus and treated with WKYMVm. The number of bacteria remaining on blood of WKYMVm-treated rats was rapidly decreased compare with control group. In vitro cell cultures, WKYMVm increase bactericidal and fungicidal activities of monocytes derived from adult human peripheral blood and neonatal cord blood. 1\",\"PeriodicalId\":20531,\"journal\":{\"name\":\"Proceedings KORUS 2000. The 4th Korea-Russia International Symposium On Science and Technology\",\"volume\":\"43 1\",\"pages\":\"253-256\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings KORUS 2000. The 4th Korea-Russia International Symposium On Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/KORUS.2000.865962\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings KORUS 2000. The 4th Korea-Russia International Symposium On Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/KORUS.2000.865962","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Stimulation of bactericidal activity of umbilical cord blood monocytes by immunoactivating peptide
Seong-A Ju', Byung-Sam Kun', and Sang-Kyu Park2 Dept. of Biological Science, University of Ulsan, San-29 Moogu-2 Dong, Namgu, Ulsan 680-749, Korea and 2College of Medicine, University of Ulsan, Ulsan 682-060, Korea Tel: +82(52)2592393, Fax: +82(52)2591694 E-mail: Sang@uuh.ulsan.kr Abstract Mononuclear phagocytes play a central role in the host defense against infections. We report that synthetic novel peptide, WKYMVm which is In vivo tests, WKYMVm increase killing activities of monocytes against S. aureus. Rats were preinfected with S. aureus and treated with WKYMVm. The number of bacteria remaining on blood of WKYMVm-treated rats was rapidly decreased compare with control group. In vitro cell cultures, WKYMVm increase bactericidal and fungicidal activities of monocytes derived from adult human peripheral blood and neonatal cord blood. 1
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