他汀类药物对慢性肾病患者的影响是什么?

F. Mendes, Eduarda Carias, André Fragoso, A. P. Silva, P. Neves
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引用次数: 0

摘要

血脂异常在慢性肾脏疾病(CKD)患者中具有很高的患病率,并有助于心血管发病率和死亡率的升高,以及肾脏疾病的进展。关于他汀类药物的肾保护作用,由于其降脂作用和多效性,在文献中存在一些争议在肾脏疾病的早期阶段使用他汀类药物可以增强肾脏保护作用,但这可能是剂量依赖性的。一些研究表明,延长治疗时间可以增强肾脏保护
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What is statins legacy in chronic kidney disease patients?
Dyslipidemia has a high prevalence among patients with chronic kidney disease (CKD) and contribute to the elevated cardiovascular morbidity and mortality, as well as to the progression of the renal disease. Regarding statins renal protective role, owing to their lipid lowering effect, and also to their pleiotropic properties there is some controversy in the literature.1 The use of statins in earlier kidney disease stages could increase renal protection but it might be dosedependent. Some studies suggest that a more prolonged treatment could increase renal protection.1,2
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