结膜下注射曲安奈德治疗标准治疗难治性慢性复发性巩膜炎的疗效观察

G. N. Chernov
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摘要

的目标。目的:评价结膜下注射曲安奈德治疗标准治疗方案无效的慢性复发性巩膜炎的安全性和有效性。材料和方法。观察3例复发性外巩膜炎,局部类固醇、非甾体类抗炎药治疗疗效低,病程超过6个月的患者。所有患者均按原方法在结膜下注射配制好的曲安奈德溶液(用0.9%生理溶液1:1稀释)1次。没有开其他药物。分别于给药前、给药后第3、7、21天、3、6个月对视觉分析仪的功能进行全面检查和评价。结果。所有患者均取得了显著的临床效果,在整个观察期内无复发。结论。结膜下注射曲安奈德被证明是有效和安全的治疗对标准治疗方案耐药的巩膜炎。这种治疗方法未发现药物副作用(并发后囊下白内障、持续性眼压升高等)。关键词:巩膜炎,长效糖皮质激素,曲安奈德,曲安奈德,结膜下注射
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Efficacy of subconjunctival injections of triamcinolone acetonide in the treatment of chronic recurrent episcleritis refractory to standard therapy
Aim. To evaluate the safety and efficacy of the treatment of chronic recurrent episcleritis, not amenable to the standard treatment regimen, by subconjunctival injections of triamcinolone acetonide. Material and methods. Three patients with recurrent episcleritis, low efficacy of treatment with local steroid, non-steroidal anti-inflammatory drugs and a disease duration of more than 6 months were under observation. All were injected with a prepared solution of triamcinolone acetonide (diluted 1:1 with physiological solution 0.9%) subconjunctivally, once according to the original method. No other drugs were prescribed. A comprehensive examination and assessment of the functions of the visual analyzer was carried out before and after the administration of the drug on the 3rd, 7th, 21st days, 3, 6 months. Results. All patients achieved a pronounced clinical effect and there were no relapses throughout the entire observation period. Conclusion. Subconjunctival injections of triamcinolone acetonide proved to be effective and safe in the treatment of episcleritis resistant to the standard treatment regimen. Side effects of the drug (complicated posterior subcapsular cataract, persistent ophthalmohypertension, etc.) were not detected with this method of treatment. Keywords: episcleritis, long-acting glucocorticosteroids, triamcinolone, triamcinolone acetonide, subconjunctival injection
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