蛋白质结合对DNA g -四重结构的影响

International Review of Biophysical Chemistry Pub Date : 2011-08-30 DOI:10.15866/IREBIC.V2I4.1525

Luca Ginnari-Satriani, V. Casagrande, A. Alvino, Alessandro Altieri, Pierre Murat, E. Defrancq, C. Lombardo, S. Neidle, A. Bianco, G. Ortaggi, M. Franceschin

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摘要

我们在这里报告了基于三氮祖昔烯的g -四重体配体和三个衍生物对g -四重体结构的结合亲和力及其对双工DNA的选择性的研究。母体化合物AZATRUX在亲和性和选择性方面都是该系列中最好的化合物

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Effects of Protein Binding on DNA G-Quadruplex Structures

We report here a study of the binding affinity of a triazatruxene based G-quadruplex ligand and three derivatives to G-quadruplex structures and their selectivity with respect to duplex DNA. The parent compound AZATRUX is the best compound of the series, both in terms of affinity and selectivity

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International Review of Biophysical Chemistry

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