苹果酚类化合物膳食浓缩物对实验性大鼠溃疡模型的抗溃疡活性研究。

L. Galuzinska, V. Kravchenko, G. Kravchenko, T. Briukhanova, V.Р. Fylymonenko
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引用次数: 0

摘要

药用植物已被广泛应用于多种疾病的治疗,特别是在胃肠病学方面,由于临床使用合成抗溃疡药物往往会产生各种副作用,因此有大量的禁忌症。本实验的目的是研究苹果酚类化合物食物浓缩物对实验性大鼠溃疡模型的抗溃疡活性。材料和方法。研究包括两个阶段,在模型上进行:第一阶段——酒精-强的松龙大鼠胃溃疡模型;第二阶段——根据乌克兰卫生部安全委员会的方法建议,采用吲哚美辛大鼠胃溃疡模型。所研究的浓缩物以基于多酚总含量的剂量给予-每100克重量9毫克。槲皮素5 mg / kg和雷尼替丁20 mg / kg作为对照药。复制模型后,对胃粘膜进行宏观检查,测定胃匀浆中tba -反应物和还原性谷胱甘肽的含量。结果。病理条件下,苹果酚类化合物食品浓缩物与参比药物在溃疡缺损程度上的治疗效果相当。实验证明,苹果酚类化合物食品浓缩物和参比药物抑制脂质过氧化反应过程,支持内源性抗氧化防御系统。结论。所获得的结果使得有可能建议进一步研究苹果酚类化合物的食物浓缩物,以便在其基础上创造药物制剂。该浓缩物的一个很有前途的应用领域是预防和治疗胃溃疡
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Research of antiulcer activity of dietary concentrate of phenolic compounds of apples on models of experimental ulcer in rats.
Medicinal plants have been widely used in the treatment of many diseases, especially in the gastroenterology, given that the use of synthetic antiulcer drugs in clinical practice often leads to the development of various kinds of side effects and, accordingly, have a large list of contraindications. The aim of this experimental work was the study of the antiulcer activity of the food concentrate of phenolic compounds of apples on the models of experimental ulcers in rats. Materials and methods. The studies included two stages, which were carried out on models: stage I – a model of alcohol–prednisolone stomach ulcer in rats, stage II – a model of indomethacin stomach ulcer in rats in accordance with the methodological recommendations of the SEC of the Ministry of Health of Ukraine. The studied concentrate was administered in a dose based on the total content of polyphenols – 9 mg per 100 g of weight. Quercetin at a dose of 5 mg / kg and ranitidine at a dose of 20 mg / kg were used as reference drugs. After replicating the models, a macroscopic examination of the gastric mucosa was carried out and the content of TBA-reactants and reduced glutathione in the stomach homogenate was determined. Results. Under pathological conditions, the therapeutic effect of the food concentrate of phenolic compounds of apples and reference drugs was comparable in terms of the degree of ulcer defect. It was proved that food concentrate of phenolic compounds of apples and reference drugs inhibit the course of lipid peroxidation reactions and support endogenous antioxidant defense systems. Conclusions. The obtained results make it possible to recommend a further study of the food concentrate of phenolic compounds of apples for the creation of a pharmaceutical preparation on its basis. A promising area of application of this concentrate will be the prevention and treatment of gastric ulcer
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