头孢醌的特性、性质及分析方法综述

S. Shantier
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引用次数: 2

摘要

自17世纪以来,药物就被用于治疗传染病。然而,随着对选择性毒性原理、微生物病原体与药物之间特定化学关系、耐药性的发展以及联合治疗的作用的理解,化疗作为一门科学开始于20世纪的第一个十年。对这些药物进行分析,无论是用于治疗人类还是动物疾病,对于了解生物利用度和治疗控制至关重要,这将确保其活性和安全性。因此,本文旨在重点介绍头孢醌的特点,特别是文献报道的药代动力学参数和分析方法。头孢醌是第四代头孢菌素,用于治疗革兰氏阳性和革兰氏阴性微生物引起的感染。
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Characteristics, Properties and Analytical Methods of Cefquinome - A Review
: Drugs have been used for the treatment of infectious diseases since the 17 th century. However, chemotherapy as a science began in the first decade of the 20 th century with understanding of the principles of selective toxicity, the specific chemical relationships between microbial pathogens and drugs, the development of drug resistance and the role of combined therapy. Analysis of such drugs, whether used for treatment of human or animal illness, is essential in understanding the bioavailability and therapeutic control which will ensure their activity and safety. Thus, this review aims to highlight the characteristics, specifically the pharmacokinetic parameters and the analytical methods reported in literature for cefquinome, a fourth generation cephalosporine used to treat infections caused by gram-positive and gram-negative microorganisms.
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