创伤后应激障碍患者脑源性神经营养因子基因的民族差异研究综述

Liumei Luo, Jun-Cheng Guo, Xiang Li, M. Guo, Ping Huang
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引用次数: 1

摘要

在对人类神经系统、认知功能等基因的调控中,表观遗传学是在受到外界环境的影响后改变基因的表达。不同族群的DNA甲基化水平也不同,大量研究表明创伤后应激障碍(PTSD)具有一定的遗传易感性。通过PTSD脑源性神经营养因子基因的国家差异,不仅为5- ht相关精神疾病的发病机制和治疗提供了新的研究方向,也为法医鉴定、亲子鉴定和精神状态评估提供了信息和新的遗传指标。创伤后应激障碍患者脑源性神经营养因子基因的国家差异研究综述。
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A Review of Studies on Ethnic Differences of Brain-Derived Neurotrophic Factor Genes in Patients with Post-Traumatic Stress Disorder
In the regulation of human nervous system, cognitive function and other genes, epigenetics changes the expression of genes after being influenced by the external environment. DNA methylation levels are also different in different ethnic groups, and a large number of studies have shown that post-traumatic stress disorder (PTSD) has a certain genetic predisposition. Through the national differences of PTSD brain-derived neurotrophic factor genes, it not only provides new research directions for the pathogenesis and treatment of 5-HT-related mental diseases, but also provides information and new genetic indicators for forensic personal identification, paternity testing and assessment of mental status. A review studies on the national differences of brain-derived neurotrophic factor genes in patients with post-traumatic stress disorder.
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