兰科植物三萜提取物的抗增殖和抗炎活性

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-11-30 DOI:10.37360/blacpma.23.22.6.58

Nadir Jordamovc, B. Pehlivanovic, H. Niksic, Irma Gusic, Emina Koric, M. Dedić, Belma Tuna-Repovac, F. Becic, K. Duric

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引用次数: 0

摘要

三萜是一种重要的次生代谢产物，具有广泛的结构多样性，在药学和医学领域具有重要作用。本研究对几种Lamiaceae植物中三萜的药理活性进行了比较研究。使用基于四氮唑盐的标准增殖试验进行体外抗增殖活性。体外抗炎活性通过抑制白蛋白变性测定三萜组分。总的来说，从Lamiaceae科植物中提取的三萜具有较强的抗增殖活性和抗炎活性。其中，三萜部位的抗增殖活性最强(gi50范围为4 ~ 37 μg/ml)，抗炎活性最强(57.27% ~ 80.69%)。本比较研究为传统医学上使用紫叶属植物作为抗炎和抗增殖药物提供了科学依据。

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Anti-proliferative and anti-inflammatory activity of triterpene extracts from plant species belonging to Lamiaceae family

Triterpenes are very important secondary metabolites with wide structural diversity and significant role in pharmacy and medicine.In the present research, a comparative study of pharamacological activities of the triterpene fractions obtained from several plant species belonging to Lamiaceae family, was carried out. In-vitro anti-proliferative activity was performed using a standardproliferation assay based on tetrazolium salts. In vitro anti-inflammatory activity of triterpene fractions was determined by an assay of inhibition of albumin denaturation. In general, the triterpene fractions obtained from plant species belonging to Lamiaceae family showed a strong anti-proliferative activity and anti-inflammatory activity.The triterpene fraction of Rosmarini folium showed the strongest anti-proliferative activity (GI50range from 4 to 37 μg/ml) and the strongest anti-inflammatory activity in the range from 57.27% to 80.69%. This comparative study provides scientific evidence to support the traditional use of Lamiacae plant species for medical purposes as anti-inflammatory and anti-proliferative medicines.

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.