TLR-3在婴幼儿轮状病毒感染过程和结局中的作用

S. G. Gorbunov, L. Mazankova, A. N. Os’kin
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引用次数: 1

摘要

研究发现,最初表达TLR-3的免疫活性细胞数量较少的婴儿轮状病毒感染的临床表现与最初表达TLR-3的细胞数量较多的婴儿轮状病毒感染的临床表现没有显著差异。在分析治疗时发现,由于细菌菌群的激活而进行的抗菌治疗仅用于最初表达TLR-3的免疫活性细胞数量较低的儿童。在同一组患者中,在轮状病毒感染后6-12个月的动态观察中,发现了特应性皮炎和食物过敏的发生。
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The role of TLR-3 in the course and outcomes of rotavirus infection in infants
It was found that the clinical picture of rotavirus infection in infants with an initially low number of immunocompetent cells expressing TLR-3 does not differ significantly from that of patients with an initially large number of cells expressing TLR-3. When analyzing the treatment, it turned out that antibacterial therapy due to the activation of bacterial microflora was used only in children with an initially low number of immunocompetent cells expressing TLR-3. In the same group of patients, the development of atopic dermatitis and food allergies was noted during catamnestic observation for 6—12 months after rotavirus infection.
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