纳米颗粒药物体外释放研究

S. Manchanda
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引用次数: 0

摘要

近年来,纳米科学和纳米技术领域的研究和应用取得了前所未有的发展。人们越来越乐观地认为,应用于医学的纳米技术将在疾病的诊断和治疗方面取得重大进展。预计在医学上的应用包括药物输送,体外和体内诊断,营养药品和生产改进的生物相容性材料。碳纳米材料具有许多独特的内在物理和化学性质,近年来在生物和生物医学领域得到了广泛的应用。所提出的工作是使用碳纳米纤维作为药物输送到所需部位的载体方向的前奏。研究了功能化碳纳米纤维在不同温度和pH条件下对抗癌药物阿霉素的释放。载药抗癌药在酸性介质中释放效果较好。此外,随着温度的升高,释放量增加。
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In vitro Release Study of Drug from Nano Particle
Recent years have witnessed unprecedented growth of research and applications in the area of nanoscience and nanotechnology. There is increasing optimism that nanotechnology, as applied to medicine, will bring significant advances in the diagnosis and treatment of disease. Anticipated applications in medicine include drug delivery, both in vitro and in vivo diagnostics, nutraceuticals and production of improved biocompatible materials. Carbon Nanomaterials exhibit many unique intrinsic physical and chemical properties and have been intensively explored for biological and biomedical applications in the past few years. The presented work is a prelude in the direction of using Carbon Nano fibers as a vehicle for drug delivery to the desired sites. Release study of the anti cancer drug, Doxorubicin from the functionalized Carbon Nano fibers at different temperature and pH conditions were studied. Loaded anticancer drug shows better release in acidic medium. Moreover, increased release is seen with the increase in temperature.
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