面向高质量皮质电成像记录的面内屏蔽柔性微电极阵列

Feihonv Xu, Zhitao Zhou, Haovuan Li, Xiaoling Wei, T. Tao
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引用次数: 0

摘要

我们报道了一组具有平面内屏蔽设计的柔性微电极阵列(MEAs),能够高质量的皮质电成像(ECoG)信号采集。在这项工作中,我们设计并制作了两种不同形状的屏蔽线(即钩形和钟形导线),并评估了它们的屏蔽性能。通过屏蔽,我们的柔性mea具有更好的抗外部干扰能力,同时保持与高质量信号的良好一致性。我们通过模拟和体外实验对两种屏蔽设计的效率进行了评估,结果表明钟形屏蔽装置具有更好的性能。作为概念验证,我们将该装置植入小鼠模型的大脑,并成功记录了高信噪比(SNR)的神经信号。
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Flexible Microelectrode Arrays with In-Plane Shielding for High Quality Electrocorticography Recording
We report a set of flexible microelectrode arrays (MEAs) with in-plane shielding designs that are capable of high quality electrocorticography (ECoG) signal acquisition. In this work, we have designed and fabricated two different shapes of shielding (i.e. hook-like and bell-type wires) and evaluated their shielding performances. With shielding, our flexible MEAs have better resistance to external disturbances while maintaining good conformability with high-quality signals. We have performed both simulation and in vitro experiments to evaluate the efficiency of two shielding designs, showing that bell-type devices have better performance. As a proof-of-concept, we implanted the device on the brain in a mouse model and high signal-to-noise ratio (SNR) neural signals have been recorded successfully.
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