洞察COVID-19及其对肾功能障碍的潜在影响

A. Abdel-Moneim, Eman H. Bakry, M. Zaky
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引用次数: 0

摘要

由严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)引起的2019年冠状病毒病(COVID-19)对世界人口产生了重大影响,导致全球600多万人死亡。COVID-19与各种器官系统的多种疾病表现有关,除了肺部表现外,还包括肾脏疾病。感染SARS-CoV-2不仅会导致新的肾脏损害,还会使治疗和护理变得更加困难,并增加已经患有肾脏问题的人的死亡率。COVID-19确实与多种肾脏病理相关,如急性肾小管坏死、蛋白尿、血尿和血栓并发症。细胞因子风暴、低氧血症、病毒通过血管紧张素转换酶2和组织蛋白酶L的直接入侵、电解质失衡和发烧是这些临床症状的病理生理机制。在过去两年中,已经发现了许多COVID-19疫苗。然而,在接受COVID-19疫苗接种后,有少数病例报告出现AKI、AKD、蛋白尿、水肿、血尿和其他肾脏副作用,需要住院治疗。因此,本综述旨在根据最新发现,从临床特征、发病机制、长期结局和疫苗危害等方面评估covid -19诱导的肾功能障碍。
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Insights into COVID-19 and Its Potential Implications for Kidney Dysfunction
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a significant impact on the world’s demographics, resulting in over 6 million deaths globally. COVID-19 has been associated with a variety of disease manifestations in various organ systems, including kidney disease, in addition to pulmonary manifestations. Infection with SARS-CoV-2 can not only cause new kidney damage but also make treatment and care more difficult, as well as increase mortality in people who already have kidney problems. COVID-19 is indeed associated with a variety of renal pathologies, such as acute tubular necrosis, proteinuria, hematuria, and thrombosis complications. Cytokine storms, hypoxemia, direct viral invasion via angiotensin-converting enzyme 2 and cathepsin L, electrolyte imbalance, and fever are among the pathophysiological mechanisms underlying these clinical symptoms. Over the last two years, many COVID-19 vaccines have been discovered. However, there have been a few case reports of AKI, AKD, proteinuria, edema, gross hematuria, and other renal side effects that necessitated hospitalization after receiving COVID-19 vaccinations. Thus, the current review aimed to evaluate COVID-19-induced kidney dysfunction in terms of clinical features, pathogenesis, long-term outcomes, and vaccine harms based on the most up-to-date findings.
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来源期刊
Journal of International Translational Medicine
Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
0.00%
发文量
317
审稿时长
8 weeks
期刊介绍: Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.
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