纳米磷酸钙配合物改性盐酸壳聚糖溶液的性能研究

L. Pighinelli, M. Guimarães, Paz Rl
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引用次数: 1

摘要

大自然本身使用纤维素等材料来提供植物的结构,几丁质作为几种昆虫和软体动物的外骨骼,胶原蛋白在结缔组织中提供机械支持等等。目前,现代社会的社会经济状况提高了人们对可再生材料用于再生医学的兴趣。壳聚糖和/或磷酸钙的组成来源于两种或两种以上不同材料的结合,其中含有有机和无机材料,包括这两种材料的特征,如生物活性和生物可降解性以及与人体组织的生物相容性。壳聚糖和纳米B-TCP / HAp配合物的化学性质表明,材料中既有有机组分,也有无机组分,在壳聚糖盐溶液中形成纳米陶瓷具有良好的稳定性。通过Zeta-Potential络合,显示了一种以微粒径的商品磷酸钙为原料,在壳聚糖溶液中制备纳米磷酸钙的新方法。这些材料可以在未来的医疗应用中作为支架生产的基础和再生医学的植入物。组织科学与工程学报[J] .中国生物医学工程学报
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Properties of hydrochloric chitosan solutions modified with nano-calcium phosphate complex
Nature itself uses materials like cellulose to provide the structure of plants, chitin as the exoskeleton of several insects and molluscs, collagen for mechanical support in connective tissues and so on. At present, the socioeconomic situation of the modern world has raised the interest in renewable materials to use in regenerative medicine. The composition of Chitosan and/or Calcium Phosphates are derived from the junction of two or more different materials, containing organic and inorganic materials, including characteristics of both materials like bioactivity and biodegradability and biocompatibility with human tissues. The chemical characteristics of chitosan and nano B-TCP / HAp complex showed that both of the components organic and inorganic exist in the material showing a good stability of the nano-ceramic formation in the chitosan salt solutions. All complex by Zeta-Potential, showing also a new method of preparations nanoparticles of calcium phosphates in chitosan solution from commercial calcium phosphates in micro size. These materials can be used in future for medical applications as a base for scaffolds production and as implants in regenerative medicine. Journal of Tissue Science & Engineering J o u r n a l o f T iss ue S cience &ngine e r i n g
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