Acute administration of fructans increases the number of transient lower esophageal sphincter relaxations in healthy volunteers

Dietary measures are often advised to patients with gastro‐esophageal reflux disease (GERD). Fermentable Oligo‐, Di‐, Mono‐saccharides and Polyols (FODMAPs) induce lower gastrointestinal (GI) symptoms. However, their effects on esophageal motility, including transient lower esophageal sphincter relaxations (TLESRs), reflux events and GERD symptoms are unknown. We investigated the effect of acute administration of two FODMAPs, fructose, and fructans, on the number of TLESRs, reflux episodes and symptom perception in healthy volunteers (HVs).