孕产妇免疫力对中低收入国家轮状病毒疫苗效果下降的影响。

Q2 Biochemistry, Genetics and Molecular Biology Clinical and Vaccine Immunology Pub Date : 2017-01-05 Print Date: 2017-01-01 DOI:10.1128/CVI.00405-16

Katayi Mwila, Roma Chilengi, Michelo Simuyandi, Sallie R Permar, Sylvia Becker-Dreps

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引用次数: 0

摘要

本文评估了婴儿经胎盘或从母乳中获得的母体免疫力对轮状病毒疫苗（RV）效果的影响。暂停母乳喂养对疫苗反应没有影响，但较高水平的经胎盘轮状病毒特异性 IgG 抗体会导致疫苗血清转换率降低。关于中低收入国家（LMIC）轮状病毒疫苗低效相关因素的知识仍然存在差距，需要进一步的研究来揭示这些问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries.

The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low- and middle-income countries (LMIC) remain, and further research is needed to shed more light on these issues.

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来源期刊

Clinical and Vaccine Immunology 医学-传染病学

CiteScore

2.88

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： Cessation. First launched as Clinical and Diagnostic Laboratory Immunology (CDLI) in 1994, CVI published articles that enhanced the understanding of the immune response in health and disease and after vaccination by showcasing discoveries in clinical, laboratory, and vaccine immunology. CVI was committed to advancing all aspects of vaccine research and immunization, including discovery of new vaccine antigens and vaccine design, development and evaluation of vaccines in animal models and in humans, characterization of immune responses and mechanisms of vaccine action, controlled challenge studies to assess vaccine efficacy, study of vaccine vectors, adjuvants, and immunomodulators, immune correlates of protection, and clinical trials.