联立方程法(Vierodt法)述评

Amit J. Vyas, Shalini Anilkumar Jha, A. Patel, AI Patel, S. R. Shah, D. Sheth
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引用次数: 3

摘要

本文对联立方程法(Vierodt法)作了简要回顾。该方法适用于光谱有适当重叠的药物的估计,即如果样品中含有两种吸收药物,每一种药物在λmax处吸收另一种药物,则可以用联立方程法技术确定两种药物。本文介绍了维罗特法分析的各种组合剂型和食品样品的波长、线性范围和溶剂的选择。该方法简便、快速、直接地测定复方剂型,无需预先分离,可用于常规分析。在任何药物进入市场之前,定量评估是必要的,因为如果配方中的浓度过高,可能会导致毒性问题,或者如果浓度过低,那么配方在规定剂量下就不会有效。
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Review on Simultaneous Equation Method (Vierodt’s Method)
The article consists of brief review on Simultaneous equation method (Vierodt’s method). This method is applicable for estimation of those drugs whose spectra overlap properly I.e. If a sample contains two absorbing drug each of which absorbing at λmax of the other, it is possible to determine both drugs by technique of simultaneous equation method. This article consists of the list of various combined dosage form and food sample analyzed by Vierodt’s method with its wavelength, linearity range and choice of solvents. This method permits simple, rapid and direct determination of combined dosage form without prior separation and therefore can be used in routine analysis. Quantitative estimation is necessary before introduction of any drug into the market because if concentration is more in formulation it can lead to toxicity problem or if concentration is found less, then formulation will not be effective in prescribed dose.
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